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Journal of the Korean Academy of Rehabilitation Medicine 2008;32(1):1-8.
Antinociceptive Effect of Botulinum Toxin A in Persistent Muscle Pain Rat Model.
Chae, Jin Mok , Sohn, Min Kyun , Lee, Mi Young , Yoon, Ki Seok , Lee, Sheng Huo , Kim, Bong Ok
1Mirae Rehabilitation Medicine Clinic, Korea.
2Institute for Brain Research, Department of Rehabilitation Medicine, College of Medicine, Chungnam National University, Korea. mksohn@cnu.ac.kr
3Department of Rehabilitation Medicine, The First Clinical College of Harbin Medical University, China.
지속적 근육통 모델 쥐에서 보툴리눔 독소 A의 통증 억제 효과
채진목, 손민균1, 이미영1, 윤기석1, 이승활2, 김봉옥1
미래재활의학과의원, 1충남대학교 의과대학 재활의학교실, 뇌과학연구소, 2The First Clinical College of Harbin Medical University
To investigate the effects of botulinum toxin on the mechanical hyperalgesia, electrophysiology and motor functions in the persistent muscle pain rat model.
A secondary mechanical hyperalgesia in the bilateral hindpaws of Sprague-Dawley rats was produced by the repeated injections of acidic saline into gastrocnemius. Botulinum toxin A (BTX-A(4): 4 U/kg, BTX-A(7): 7 U/kg) was administrated into same muscle 24 hours after a second injection of saline. The mechanical hyperalgesia was measured with withdrawal threshold to von Frey filament. The grade of muscle paralysis was evaluated with electrophysiology and the locomotor performance using inclined plane board.
The mechanical hyperalgesia was significantly decreased from 5 days to 2 weeks in BTX-A(7) group in the injected side. The dose-dependent decreased amplitude of compound muscle action potential and reduced prevalence of endplate noise from the first day of botulinum toxin injection lasted for 4 weeks in both gastrocnemius. The maximum angle maintained at initial position on the inclined plane board did not change.
Local muscular injection of botulinum toxin A reduced ipsilateral hyperalgesia dose-dependently in per- sistent muscle pain rat model without motor deficit. The antinociceptive mechanism of botulinum toxin might act at a local or peripheral rather than a systemic or central effect due to ineffectiveness of contralateral hyperalgesia. Clini- cally, botulinum toxin A might be useful for the treatment of local and referred pain of muscle origins. (J Korean Acad Rehab Med 2008; 32: 1-8)
Key Words: Persistent muscle pain, Botulinum toxin, Rat model


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