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Journal of the Korean Academy of Rehabilitation Medicine 2000;24(4):587-593.
Effects of Clonidine and Yohimbine on Neuropathic Pain in a Rat Model.
Yang, Jung Hoon , Song, Eun Beom , Kim, Sei Joo , Lee, Sang Heon , Na, Heung Sik
1Department of Rehabilitation Medicine, Korea University College of Medicine.
2Department of Physiology, Korea University College of Medicine.
실험적으로 유발된 흰쥐 신경병변성 통증에 대한 Clonidine과 Yohimbine의 효과
양정훈, 송은범, 김세주, 이상헌, 나흥식1
고려대학교 의과대학 재활의학교실, 1생리학교실

In a rat model of peripheral neuropathy, to determine whether neuropathic pain is related to the α-2 adrenergic receptor.

The neuropathic pain was produced by unilateral transection of the superior caudal trunk between the S3 and S4 spinal nerves. These animals showed the behavioral signs of neuropathic pain in the tail. Two weeks after the neuropathic surgery, tail withdrawal responses to the mechanical stimuli with von Frey hair (2.0 g) were examined 1, 2 and 24 hrs following the administration of clonidine, α-2 receptor agonist. One week after the clonidine test, the same behavioral test was done after the administration of clonidine along with yohimbine, α-2 receptor antagonist.

Clonidine significantly reduced the frequency of tail response and yohimbine reversed the clonidine-induced anti-allodynic effect.

These results suggest that neuropathic pain is related to the sympathetic nervous system via α-2 adrenergic receptor.

Key Words: Neuropathic pain, Allodynia, Clonidine, Yohimbine, Sympathetically mediated pain


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