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Journal of the Korean Academy of Rehabilitation Medicine 2002;26(3):279-284.
Comparing the Effect of Two Doses of Botulinum Toxin A (Dysport(R)) for Treatment of Calf Muscle in Spastic Cerebral Palsy.
Bang, Moon Suk , Lee, Shi Uk , Park, Jin Woo , Kim, Sang Jun
1Department of Rehabilitation Medicine, Seoul National University College of Medicine, Korea.
2Department of Rehabilitation Medicine, Boramae Municipal Hospital, Korea.
경직형 뇌성마비의 치료에 있어 디스포트의 두 용량에 대한 효과 비교
방문석, 이시욱1, 박진우, 김상준
서울대학교 의과대학 재활의학교실, 1시립 보라매병원 재활의학교실

To determine the effective and safe dose of Dysport (one of the commercial botulinum toxins) for relieving the spasticity of calf muscle in cerebral palsy.

Twenty spastic cerebral palsy children (34 limbs) were randomly assigned to a high dose (HD; 16 Unit/ kg/limb) injection group and low dose (LD; 8 Unit/kg/limb) injection group. Locomotor rating scale (LRS) and parameters of 3 dimensional gait analysis including ankle dorsiflexion angle at stance phase (MADA), maximal dynamic gastrocnemius (MDGL) and soleus length (MDSL) were assessed before, 4 weeks after, and 12 weeks after injection.

Mean LRS, MADAs, MDGLs and MDSLs were significantly increased both 4 and 12 weeks after injection in HD group. In LD group, LRS, MADAs, MDGLs and MDSLs showed some improvement but they were statistically insignificant. The high dose had no adverse effect except the mild and transient weakness, which was tolerable to the cerebral palsy patients.

The present study demonstrated the high dose injection of Dysport was more effective than the low dose injection to relieve the spasticity of calf muscle in cerebral palsy. (J Korean Acad Rehab Med 2002; 26: 279-284)

Key Words: Calf muscle, Cerebral palsy, Dysport, Calf muscle, Spasticity


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