J Korean Acad Rehabil Med Search


Journal of the Korean Academy of Rehabilitation Medicine 2001;25(1):117-122.
Usefulness of Current Withdrawal Threshold on Evaluation of the Neuropathic Pain in Animal Model.
Song, Eun Beom , Yang, Jung Hoon , Kang, Yoon Kyoo , Kim, Sei Joo
1Department of Rehabilitation Medicine, Samyook Rehabilitation Hospital.
2Department of Rehabilitation Medicine, Korea University College of Medicine.
신경병변성 실험 동물 모델의 통증 검사에 전류 자극 역치의 유용성
송은범, 양정훈1, 강윤규1, 김세주1
삼육재활병원 재활의학과, 1고려대학교 의과대학 재활의학교실

To evaluate usefulness of the current withdrawal threshold (CWT) on evaluation of the neuropathic pain in animal model.

Surgical neuropathy was induced in 40 Sprague-Dawley rats. Fourteen days after the surgery, neuropathic rats were evaluated by von Frey hair. The CWT was determined by various stimulus intensities which induce the tail-withdrawal response or vocalization of rats. The experimental group was compared with the control group by CWT. Then the experimental group was subdevided to two groups. The experimental group 1 was injected with beta-methasone 0.1 mg/kg, intra-peritoneally and experimental group 2 was injected with normal saline with the same amount as steroid. The CWT of two experimental subgroups were measured before and 30 minutes after injections.

The experimental group showed significant decrease of the CWT compared with the control group after the neuropathic pain was induced. The CWT of experimental group 1 was increased after steroid administration (p<0.01).

This preliminary study suggests that the measurement of CWT would be an useful tool to study the neuropathic pain in experimental animal model.

Key Words: Neuropathic pain, Current withdrawal threshold (CWT)


Browse all articles >

Terms of Use   |   Privacy Polity
Editorial Office
Department of Rehabilitation Medicine, Seoul National University Hospital
101 Daehak-ro, Jongno-gu, Seoul, Korea
Tel: +82-10-8678-2671    Fax: +82-2-6072-5244    E-mail: edit@e-arm.org; edit.karm@gmail.com
Business Registration: 110-82-07460                

Copyright © 2024 by Korean Academy of Rehabilitation Medicine.

Developed in M2PI

Close layer