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Journal of the Korean Academy of Rehabilitation Medicine 2001;25(2):315-320.
The Effect of Gabapentin and Clonidine on Neuropathic Pain in an Experimental Pain Model.
Lee, Ki Hoon , Jung, Tae Doo , Lee, Yang Soo , Ki, Poong Taek
Department of Rehabilitation Medicine, Kyungpook National University College of Medicine.
Gabapentin과 Clonidine이 신경병변성 동통을 유발시킨 흰쥐의 동통에 미치는 효과
이기훈, 정태두, 이양수, 김풍택
경북대학교 의과대학 재활의학교실

To evaluate the effects of gabapentin and clonidine on neuropathic pain in an experimental pain model.

24 male adult rats were anesthetized and the sciatic nerve was exposed. Each exposed nerve was electrically injured with 10 volts for 10 seconds by two needle electrodes. Rats were divided into three groups by treating with gabapentin, clonidine and sham. Gabapentin and clonidine were given orally from post operation day 3 to 7 in gabapentin and clonidine groups respectively. To evaluate the presence of mechanical allodynia, withdrawal frequency was tested by Von Frey hair in the same days. After post operation day 7, all the medications were discontinued and mechanical allodynia was evaluated at post operation day 14.

Result: Neuropathic pain was developed after electrical injury in all the rats. Withdrawal frequency is more decreased in gabapentin and clonidine groups than sham group in post operation day 4 to 7. The withdrawal frequency was 2.88⁑0.83, 2.75⁑0.89, 3.13⁑0.99, 3.25⁑1.28 in gabapentin group and 3.38⁑0.92, 4.50⁑2.20, 3.25⁑1.17, 3.50⁑0.93 in clonidine group in post operation day 4, 5, 6, 7, respectively. In post operation day 14, withdrawal frequency was increased and showed no difference compared to the sham group.

Gabapentin and clonidine can suppress the neuropathic pain in an experimental pain model. There was no different effect on the neuropathic pain suppression between gabapentin and clonidine.

Key Words: Gabapentin, Clonidine, Neuropathic pain, Allodynia


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