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Journal of the Korean Academy of Rehabilitation Medicine 2002;26(3):332-336.
The Effect of the Prolotherapy on the Injured Achilles Tendon in a Rat Model.
Ahn, Kyung Hoi , Kim, Hee Sang , Lee, Wo Kyeong , Kim, Hye Wan , Yun, Dong Hwan , Kim, Dong Hwan
Department of Rehabilitation Medicine, Kyung Hee University College of Medicine, Korea.
흰쥐의 실험적 아킬레스건 손상에서 증식치료의 효과
안경회, 김희상, 이우경, 김혜완, 윤동환, 김동환
경희대학교 의과대학 재활의학교실

The purpose of this study was to evaluate the effects of the prolotherapy on the healing of the tendon tissue and the proliferation of fibroblasts in the injured Achilles tendons.

The tendons of twenty eight Sprague-Dawley rats were transected at 2 mm above the calcaneal insertion in the right Achilles tendon and sutured. Then they were allocated randomly into two groups: prolotherapy group and control group. We injected 20% dextrose 0.1 ml on injured tendon area of prolotherapy group immediately after transection. After 2 and 4 weeks, the diameters of tendons were measured on both the injured and uninjured tendon. The number of fibroblasts and the ratio of fibroblast to fibrocyte on the injured tendon tissues were measured by the image analyzer.

The diameters of the injured tendons of the prolotherapy group were not significantly different with that of the control group. However, the number of fibroblasts and the ratio of fibroblast to fibrocyte in the prolotherapy group showed significantly larger and more increased than the control group (p<0.05).

This result showed the additional regeneration effect of the prolotherapy on the healing of the injured tendon tissue. Therefore, the prolotherapy would be an effective treatment on the tendon injury. (J Korean Acad Rehab Med 2002; 26: 332-336)

Key Words: Prolotherapy, Tendon, Fibroblast


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