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Original Article

The Effect of Growth Hormone on Bone Mineral Density of the Corticosteroid-Induced Osteoporosis in Rat.

Heo, Jai Kyun , Choi, Gi Seob , Lee, Sang Gun , Park, Yong Uk , Cho, Suk Shin
Journal of the Korean Academy of Rehabilitation Medicine 1999;23(4):690-694.
1Department of Rehabilitation Medicine, College of Medicine, Hanyang University, Seoul, Korea.
2Department of Pathology, College of Medicine, Hanyang University, Seoul, Korea.
3Department of Nuclear Medicine, College of Medicine, Hanyang University, Seoul, Korea.
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Objective: This study was designed to evaluate the effect of growth hormone on bone mineral density of corticosteoid-induced osteoporosis in male rat.

Method: Twenty Sprague-Dwaley male rats was studied, divided into four group, each group has 5 rats. The group 1 was treated with saline. The group 2 was treated with corticosteroid (Methylprednisolone 10 mg/kg). The group 3 was treated with corticosteroid and growth hormone (recombinant human growth hormone 0.5 IU/kg). The group 4 was treated with growth hormone after corticosteroid treatment. The treatment duration was 6 weeks for each group. After six weeks of hormone administration, the animals were sacrificed, the bilateral femur were removed and tested for bone mineral density using dual energy X-ray absorptiometry and examined histomorphometrically.

Results: Administration of growth hormone after corticosteroid therapy, the growth hormone could reverse the decrease in body weight and bone mineral density induced by corticosteroid therapy (p<0.05).

Conclusion: When growth hormone is administrated after corticosteroid therapy, the growth hormone can protect the osteoporosis in male rats induced by a high dose of corticosteroid.

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