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Journal of the Korean Academy of Rehabilitation Medicine 1999;23(4):690-694.
The Effect of Growth Hormone on Bone Mineral Density of the Corticosteroid-Induced Osteoporosis in Rat.
Heo, Jai Kyun , Choi, Gi Seob , Lee, Sang Gun , Park, Yong Uk , Cho, Suk Shin
1Department of Rehabilitation Medicine, College of Medicine, Hanyang University, Seoul, Korea.
2Department of Pathology, College of Medicine, Hanyang University, Seoul, Korea.
3Department of Nuclear Medicine, College of Medicine, Hanyang University, Seoul, Korea.
스테로이드로 유발된 쥐의 골다공증에서 성장호르몬의 치료효과
허재균, 최기섭, 이상건, 박용욱1, 조석신2
한양대학교 의과대학 재활의학교실, 1병리학교실, 2핵의학교실
Abstract

Objective
This study was designed to evaluate the effect of growth hormone on bone mineral density of corticosteoid-induced osteoporosis in male rat.


Method
Twenty Sprague-Dwaley male rats was studied, divided into four group, each group has 5 rats. The group 1 was treated with saline. The group 2 was treated with corticosteroid (Methylprednisolone 10 mg/kg). The group 3 was treated with corticosteroid and growth hormone (recombinant human growth hormone 0.5 IU/kg). The group 4 was treated with growth hormone after corticosteroid treatment. The treatment duration was 6 weeks for each group. After six weeks of hormone administration, the animals were sacrificed, the bilateral femur were removed and tested for bone mineral density using dual energy X-ray absorptiometry and examined histomorphometrically.


Results
Administration of growth hormone after corticosteroid therapy, the growth hormone could reverse the decrease in body weight and bone mineral density induced by corticosteroid therapy (p<0.05).


Conclusion
When growth hormone is administrated after corticosteroid therapy, the growth hormone can protect the osteoporosis in male rats induced by a high dose of corticosteroid.

Key Words: DXA, Osteoporosis, Corticosteroid, Growth hormone, Bone density, DXA


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