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Journal of the Korean Academy of Rehabilitation Medicine 2006;30(2):173-178.
The Effects of Hyperosmolar Dextrose and Autologous Serum Injection in the Experimental Articular Defect of Rabbit.
Kim, Soo A , Kim, Eui Han , Kim, Sang Yun , Lee, Sung Yong , Yoon, Jae Nam , Lee, Yang Kyun
1Department of Rehabilitation Medicine, Soonchunhyang University College of Medicine, Korea. sooapmr@schch.co.kr
2Department of Pathology, Soonchunhyang University College of Medicine, Korea.
3Dr. Kim's Rehabilitation Clinic, Korea.
가토에서 인위적 관절 손상 후 포도당 용액과 자가 혈청 주사 치료의 효과
김수아, 김의한1, 김상윤2, 이성용, 윤재남, 이양균
순천향대학교 의과대학 재활의학교실, 1병리학교실, 2김상윤 재활의학과의원
Although the clinical effects of prolotherapy on osteoarthritis has been reported, there have been few previous studies showing the effects as a proliferant on articular cartilage. Also the autologous blood has been reported to used as a growth factor stimulant recently, we were trying to use dextrose and autologous serum for tissue regeneration respectively and evaluated the proliferative effect of autologous serum comparing with that of dextrose.
Twenty four rabbits were used for this study. The rabbits were divided into three groups. Group A did not get any special treatment. Group B was treated with 10% dextrose and group C with autologous serum. Six weeks la-ter, gross appearance and histologic findings were evaluated.
After sacrifice, the gross inspection of the knee joints revealed that group B and C were filled with the translucent tissue in defective cartilage. Group A still had defective cartilage. Histologic evaluation revealed increase of cellularity in the defect of the injected specimens when compared with the control. There was no morphological difference between group B and C.
The repair process of the articular cartilage defects using dextrose and autologous serum were shown to be more effective than that of control group. (J Korean Acad Rehab Med 2006; 30: 173-178)
Key Words: Autologous serum, Dextrose, Articular cartilage, Proliferant


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