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Journal of the Korean Academy of Rehabilitation Medicine 2001;25(2):284-289.
Dose-Related Effects of Steroid on the Experimental Arthritis in Rabbits.
Bak, Joon Yong , Kim, Jae Seung , Kim, Bong Hee , Lee, Ji Ho , Ahn, Kyung Hoi
1Department of Rehabilitation Medicine, Nuclear Medicine.
2Diagnostic Pathology and Occupational Medicine, University of Ulsan College of Medicne.
3Department of Rehabilitation Medicine, Kyung Hee University College of Medicine.
스테로이드 용량에 따른 반복적 관절강내 주사가 연골에 미치는 영향
박준용, 김재승1, 김봉희2, 이지호3, 안경회4
울산대학교 의과대학 재활의학교실, 1핵의학교실, 2진단병리학교실, 3산업의학교실, 4경희대학교 의과대학 재활의학교실
Abstract

Objective
To investigate dose-related effects of repeated intraarticular steroid injection on the experimental arthritis.


Method
Twenty-four adult male rabbits received Zymosan A into their right knee joint for experimental arthritis. After a week, they were injected with 2 mg (group I; n=9), 10 mg (group II; n=7) or 20 mg (group III; n=8) triamcinolone acetonide into their right knee weekly interval for 4 weeks. We measured weekly changes of the weight and the mediolateral diameter of both knees for the calculation of edema index. 99mTechnetium pertechnate (99mTc) uptake measurement were performed before the first steroid injection and a week after the final steroid injection. All rabbits were sacrificed and histologic examinations of their proximal tibia were performed.


Results
A progressive weight loss and changes of edema index were evident for all rabbits (p<0.05) and difference among the groups was not found (p>0.05). 99mTc uptake significantly decreased after the steroid injection in group I (p<0.05) but it was not profound in others (p>0.05). In the histological findings, fibrillation-frayings and fissures of the surface were similar in all rabbits, but loss of nuclear stains and cyst formations were increased prominently in group III than group I (p<0.05).


Conclusion
Low-dose repeated steroid intraarticular injections are safe and effective treatment in arthritis though no definite evidence of chondroprotection, and high-dose steroid injections accelerate degeneration of the arthritic cartilage.

Key Words: Cartilage, Experimental arthritis, Steroid


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