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Journal of the Korean Academy of Rehabilitation Medicine 2001;25(6):1081-1086.
Effects of Hyperosmolar Dextrose Water on Healing of Injured Achilles Tendon in Rats.
Lee, Jung Soo , Kim, Hye Won , Kim, Jong Hyun , Choi, Yun Jung , Lee, Kyung Ah , Lee, Hyoung Chul , Ko, Young Jin
Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Korea.
고삼투압 다당류 용액이 손상된 흰쥐 아킬레스건의 치유에 미치는 효과
이정수, 김혜원, 김종현, 최윤정, 이경아, 이형철, 고영진
가톨릭대학교 의과대학 재활의학교실
Abstract

Objective
To assess the effects of intratendinous injection of 12.5% dextrose water on healing of injured Achilles tendon in rat.


Method
Quantification of hydroxyproline concentration in Achilles tendons of 21 Sprague- Dawley rats was performed to assess the concentration of collagen, and hematoxyline-eosin and immunochemistry staining was performed to analyse histopathology.


Results
There was no significant difference in collagen concentration between the three groups (p>0.05). Light microscopic examination showed irregular arrangement of coarse collagen fibers and decreased number of fibroblasts in sham treatment and dextrose injection group and showed more irregular arrangement of coarse collagen fibers in dextrose injection group than in sham treatment group. The immunochemical staining of sham treatment and dextrose injection group showed more increased immunoreactivity for type I and III collagen than control group, but the same as in sham treatment group and dextrose injection group.


Conclusion
The increase of collagen concentration in injured Achilles tendon of rat treated with hyperosmolar dextrose was not found. This implies that clinical observation of collagen remodelling process may alter biomechanical property other than collagen concentration which should be further investigated.

Key Words: Hyperosmolar dextrose water, Tendon healing


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