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Journal of the Korean Academy of Rehabilitation Medicine 2007;31(2):150-156.
The Evaluation of Neurotoxicity after Intrathecal Restorative Fluid Injection in the Rat.
Kim, Gui Sang , Yoon, Joon Sik , Kim, Sei Joo , Seo, Gwan Sik , Lee, Sang Hun , Baek, Hye Jin , Lee, Joo Han , Kim, Joo Han , Kim, Don Kyu
1Department of Rehabilitation Medicine, Korea University College of Medicine, Korea. Rehab46@medimail.co.kr
2Department of Pathology, Korea University College of Medicine, Korea.
3Department of Neurosurgery, Korea University College of Medicine, Korea.
4Department of Rehabilitation Medicine, Chung Ang University College of Medicine, Korea.
흰 쥐의 척추 경막하 증식주사제 투여 후 신경계 독성의 평가
김귀상, 윤준식, 김세주, 서관식, 이상헌, 백혜진, 이주한1, 김주한2, 김돈규3
고려대학교 의과대학 재활의학교실, 1해부병리학교실, 2신경외과학교실, 3중앙대학교 의과대학 재활의학교실
To assess neurotoxicity of intrathecal restorative fluid leakage in the course of the intradiscal restorative fluid injection.
Twenty male Sprague-Dawley rats, body weight range of 300∼350 gm, were divided randomly into four groups. Control group, group A (mixed solution of glucosamine hydrochloride 5%, chondroitin sulfate 5%, and bupivacaine hydrochloride 2%), group B (glucosamine hydrochloride 8%, chondroitin sulfate 2%, and bupivacaine hydrochloride 2%) and group C (glucosamine hydrochloride 16%, chondroitin sulfate 2%, and bupivacaine hydrochloride 2%). The behavioral test for cold allodynia (tail flick test) was conducted 1 day prior to the injection and 7 days postoperatively. Histopathologic evaluation was performed using light microscopy by a neuropathologist. The severity of nerve and cord injury were graded according to injury scoring system.
Each group showed no significant difference in sensory function test using tail flick test before and after intrathecal restorative fluid injection. Cold allodynia was not showed statistically significant difference among the group. Histological examination showed statistically significant difference between control group and group B, group C, and between group A and group B, C in both cord and root.
Intrathecal injection of restorative fluid shows neurotoxic changes in roots and spinal cord in histopathologic studies. Although same ingredients of restorative solution, the different concentration of the ingredients revealed different neurotoxicity. (J Korean Acad Rehab Med 2007; 31: 150-156)
Key Words: Neurotoxicity, Restorative injection, Intrathecal solution


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