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Journal of the Korean Academy of Rehabilitation Medicine 2002;26(4):470-474.
Evaluation of Nerve Block after Phenol and Ethanol Injection.
Kim, Sung Sik , Jang, Ki Un , Kim, Jong Chul , Lee, Ju Hyung , Jeong, Kwang Ik , Park, Dong Sik
Department of Rehabilitation Medicine, Hallym University College of Medicine, Korea.
흰쥐에서 페놀과 에탄올의 신경차단 효과의 비교
김성식, 장기언, 김종철, 이주형, 정광익, 박동식
한림대학교 의과대학 재활의학교실

To evaluate the axonal degeneration after nerve block with phenol and ethanol injection into tibial nerve.

Tibial nerves of thirty Sprague-Dawley rats were exposed. For the developement of neuropathic pain, the method of intraneural injection was performed. Five percent phenol, 90% ethanol or normal saline were injected into the epineurial sheath of tibial nerve at each group. The mechanical and thermal allodynia were evaluated in post- injection 1, 2, 3, and 4 weeks. The mechanical allodynia was evaluated by withdrawal response to 10 stimulations with von Frey hair. Thermal allodynia was tested by withdrawal response to 5 stimulations with acetone. Motor nerve conduction study was performed in post-injection 1, 2, and 4 weeks.

In behavioral test, the experimental group exhibited increased withdrawal response to mechanical and cold stimulation, but there was no significant difference between two groups, phenol and ethanol groups. In motor nerve conduction study, compound motor action potential amplitude loss were observed in experimental group, but there was no significant difference between two groups, phenol and ethanol groups.

These results suggest that axonal degeneration of ethanol is roughly similar to those of phenol block. (J Korean Acad Rehab Med 2002; 26: 470-474)

Key Words: Ethanol, Phenol, Neuropathic pain, Rat


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