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Journal of the Korean Academy of Rehabilitation Medicine 2004;28(6):559-564.
The Evaluation of Cardiac Function in Duchenne Muscular Dystrophy.
Kang, Seong Woong , Im, Sang Hui , Moon, Jae Ho , Park, Sa Yun , Hue, Hyen Seok
1Department of Rehabilitation Medicine and Rehabilitation Institute of Muscular Disease, Yonsei University College of Medicine, Korea. dongin32@yahoo.com
2Department of Rehabilitation Medicine, Samyook Rehabilitation Hospital, Korea.
뒤시엔느형 근디스트로피 환자의 심장기능 평가
강성웅, 임상희, 문재호, 박사윤1, 허현석
연세대학교 의과대학 재활의학교실 및 근육병재활연구소, 1삼육재활병원 재활의학과
Abstract
Objective
To evaluate the cardiac function and to explore the importance of the evaluation of cardiac function in patients with Duchenne muscular dystrophy (DMD).
Method
Thirty-nine patients with DMD without any symptoms of heart problems underwent physical examinations and cardiac monitoring including the arterial carbon dioxide (CO2) screening. Thirty one patients underwent pulmonary function test.
Results
Among 39 patients 27 showed abnormal electrocardiographic findings such as ventricular hypertrophy, ischemic change, atrial hypertrophy, T wave inversion, sinus tachycardia and ST elevation. 24 patients showed abnormal echocardiographic findings such as abnormal ejection fraction, dilated cardiomyopathy (DCMP), filling abnormality of left ventricle, global hypokinesia and reduced systolic function. 17 patients showed low ejection fraction (below 59%) and 4 of them were diagnosed as DCMP. There were significant correlations between age and ejection fraction (r=⁣0.552, p<0.01), between functional level and ejection fraction (r=⁣0.607, p<0.01) and between vital capacity and ejection fraction (r=0.547, p<0.01). However, ejection fraction showed no significant correlations with arterial CO2.
Conclusion
Routine evaluation of the cardiac function, at least from 10 years of age, and proper treatment following early diagnosis of heart problems were necessary in patients with DMD, because they possibly have been severely affected by cardiac problems without any clinical symptoms. (J Korean Acad Rehab Med 2004; 28: 559-564)
Key Words: Duchenne muscular dystrophy, Cardiomyopathy, Echocardiography, Electrocardiography


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