The Cri-du-Chat syndrome, first described by Lejeune in 1963, has been shown to be caused by a partial deletion of the short arm of the chromosome No. 5(5p-). The characteristic manifestations of the syndrome include severe mental retardation, microcephaly, broad nasal bridge, abnormal crying, failure to thrive, epicanthal folds, hypertelorism, abnormal ears, transverse flexion creases on the palm, and feeding difficulty.

Although the physical featlures associated with this syndrome have been documented frequently, the potential level of development has not been explored frequently. Furthermore, studies on mental handicaps of individuals with Cri-du-Chat syndrome have been based mainly on institutionalized adolescents and adults.

Physician and parents should be aware of the full range of psychomotor potential of the child with Cri-du-Chat syndrome in early period of child to make informed decisions on special schooling.

So, we describe two children with Cri-du-Chat syndrome based on assessment of psychomotor development with clinical follow up.