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Journal of the Korean Academy of Rehabilitation Medicine 1998;22(6):1225-1231.
Measuring Compound Muscle Action Potentials after Botulinum Toxin A Injection for the Quantification of Effects.
Seo, Jeong Hwan , Kim, Sang Su , Kim, Nam Kyun , Lee, Ju Hong
1Department of Rehabilitation Medicine, 1Department of Medical Engineering.
2Department of Orthopaedic Surgery, Chonbuk National University Medical School.
보툴리눔 독소 주사 효과의 정량적 분석을 위한 복합근활동전위 측정
서정환, 김상수, 김남균1, 이주홍2
전북대학교 의과대학 재활의학교실, 1의공학교실 및 2정형외과학교실

To quantify the effect of botulinum toxin A injection, by the compound muscle action potential (CMAP) measure from the gastrocnemius muscles (GCM) and to compare them with the clinical data.

Seventeen legs of 10 cerebral palsy (CP) children were studied with botulinum toxin A injection on the motor points of their GCM. Each GCM was injected up to 6 units of the botulium toxin A per kilogram of the body weight. The CMAP were measured at the motor points of GCM with the surface electrodes on the post-injection day 1, day 3, day 7, 2 weeks and at 1 month then monthly thereafter for 6 months. Physician rating scale (PRS) and the angle of passive ankle dorsiflexion were evaluated at the same time.

The amplitude and the area of the CMAP decreased from post-injection day 1 to 3 months. The most pronounced decrement was seen at 2 weeks post-injection (p<0.05). The most pronounced increase of the dorsiflexion angle and PRS were seen at 1 and 2 months post-injection, respectively (p<0.05).

The compound muscle action potential measure can be used for the neurophysiological quantification of the effect of botulinum toxin A, especially for the superficial muscles of extremities.

Key Words: Botulinum toxin A, Cerebral palsy, Physician rating scale, Compound muscle action potentials


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