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Journal of the Korean Academy of Rehabilitation Medicine 2002;26(1):55-60.
Neurophysiological Changes after Botulinum Toxin A Injection in Normal Adults.
Park, Gi Young , Kim, Hyun Ree , Kim, Jong Min , Lee, So Young
Department of Rehabilitation Medicine, Dongsan Medical Center, Keimyung University College of Medicine, Korea.
정상 성인에서 보툴리눔 독소 A 주사 후 신경생리학적 변화
박기영, 김현리, 김종민, 이소영
계명대학교 의과대학 재활의학교실

Objecive: To evaluate the neurophysiological changes after intramuscular botulinum toxin A (BTX-A) injection in normal adults.

Nine subjects were studied by electrophysiological measurements before and after the injections. BTX-A (5 IU, Botox, Allergen, USA) was injected in the extensor digitorum brevis (EDB) muscles. Thereafter, electrophysiological measurement was followed up during 6 months.

The compound muscle action potential (CMAP) amplitude of injected EDB muscle decreased significantly for 8 weeks, a maximal decrement at 4 weeks after in-

jection. CMAP peak area changes over time were nearly identical to those of CMAP peak amplitudes. The first/fourth amplitude change of CMAP with 3-Hz repetitive nerve stimulation decreased significantly for 8 weeks and the amplitude following post-exercise activation increased significantly after injection. There were no significant changes in F-wave amplitude and latency.

Serial electrophysiological measurements after intramuscular BTX-A injection into EDB provide useful information for the neurophysiological change after injection. (J Korean Acad Rehab Med 2002; 26: 55-60)

Key Words: Botulinum toxin A, Electrophysiological change, Extensor digitorum brevis


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