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Journal of the Korean Academy of Rehabilitation Medicine 2000;24(4):624-630.
Serum Lipid Profile and Prognosis of Stroke Patient according to Genotype of Apolipoprotein E.
Kim, Yun Hee , Park, Sung Hee , Shin, Yong Il , Seo, Jeong Hwan , Kim, Dal Sik
1Department of Rehabilitation Medicine, Chonbuk National University Medical School.
2Department of Clinical Pathology, Chonbuk National University Medical School.
3Institute for Medical Sciences, Chonju, Korea.
뇌졸중 환자에서 아포지단백 E의 유전자형에 따른 혈중 지질과 예후
김연희, 박성희, 신용일, 서정환, 김달식1
전북대학교 의과대학 재활의학교실, 1임상병리학교실, 의과학 연구소
Abstract

Objective
To determine allele frequencies of apolipoprotein (Apo) E according to the type of stroke in Korean and to investigate the relationship between the Apo E genotype and serum lipid profile as well as outcome after stroke.


Method
Fifty-eight stroke patients admitted between January and December 1999 were enrolled. The serum concentrations of total cholesterol, triglyceride, and HDL-cholesterol were measured. The LDL-cholesterol concentration were calculated by Friedwald formula. Apo E genotypes were determined by polymerase chain reaction (PCR) and polyacrylamide gel electrophoresis (PAGE). The outcome of stroke was measured by functional independence measure (FIM) scores.


Results
Most frequent Apo E genotype was E 3/3 (72%), followed by E 3/4 (17%), E 2/3 (9%) and E 2/2 (2%). The level of total serum cholesterol and LDL-cholesterol were lower in the stroke patients who have ε2 allele in comparison with the patients without that allele. ε4 allele does not influence on the outcome of stroke patients measured by FIM.


Conclusion
Most frequent Apo E genotype was E3/3. ε2 allele influenced on the serum cholesterol level in stroke patients. However, ε4 allele does not correlate with worse prognosis in stroke patients in this study.

Key Words: Apolipoprotein E genotype, Stroke, FIM, Cholesterol, LDL-cholesterol


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