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Journal of the Korean Academy of Rehabilitation Medicine 2002;26(3):243-248.
Severity of Disability and Serum Lipid Level according to the Genotype of Apolipoprotein E in Patients with Brain Injury.
Kim, Yun Hee , Kim, Kwan Min , Park, Sung Hee , Kim, Dal Sik
1Department of Physical Medicine and Rehabilitation, Pochon CHA University College of Medicine, Bundang CHA General Hospital, Korea.
2Department of Rehabilitation Medicine, Chonbuk National University Medical School, Korea.
3Department of Clinical Pathology, Chonbuk University Medical School, Research Institute of Clinical Medicine, Korea.
뇌병변에서 아포지단백 E의 유전자형에 따른 장애 정도와 혈중 지질 농도
김연희, 김관민1, 박성희1, 김달식2
포천중문의과대학 재활의학교실, 1전북대학교 의과대학 재활의학교실, 2임상병리학교실, 임상의학 연구소
Abstract

Objective
This study was to investigate the relationship between genotype of Apolipoprotein E (Apo E) and severity of disability after brain injury as well as serum lipid profile.


Method
One hundred thirty-five brain injured patients (mean age 54.6⁑16.7 years, 90 male and 45 female) were enrolled. There were 34 patients with ischemic Stroke, 61 hemorrhagic stroke, and 40 traumatic brain injury. Apo E genotype was determined by polymerase chain reaction and polyacrylamide gel electrophoresis. The serum concentrations of total cholesterol, triglyceride, and HDL-cholesterol were measured. The outcome of brain injury was assessed by functional independence measure (FIM) scores.


Results
Most frequent Apo E genotype was E 3/3 (72%). In hemorrhagic stroke patients with ε4 allele, FIM score at admission was significantly lower than that of the patients without ε4 allele (p<0.05). In traumatic brain injury patients with ε4 allele, FIM score change was significantly smaller than that of patients without ε4 allele (p<0.05). The level of total serum cholesterol was lower in the ischemic stroke patients who have ε2 allele in comparison with the patients without that allele.


Conclusion
The presence of ε4 allele is considered to have relationship with the severity of disability and functional outcome in the patients with brain injury. (J Korean Acad Rehab Med 2002; 26: 243-248)

Key Words: Apolipoprotein E genotype, Brain injury, FIM, Cholesterol


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