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Journal of the Korean Academy of Rehabilitation Medicine 2002;26(5):587-590.
Pain Relief Effect of Calcitonin Injection in Ovariectomized Rats.
Choi, Jeong Won , Chung, Jae Soon , Choi, Ki Soeb , Park, Si Bog , Lee, Sang Gun , Kim, Mi Jung
Department of Rehabilitation Medicine, Hanyang University College of Medicine, Korea. gardendsg@hanmail.net
난소 절제 쥐에 투여한 칼시토닌의 통증 경감 효과
최정원, 정제순, 최기섭, 박시복, 이상건, 김미정
한양대학교 의과대학 재활의학교실
Abstract

Objective
To confirm the effect of calcitonin injection relieving pain in ovariectomized rats.


Method
Thirty five Sprague-Dawley rats were randomly divided into five groups (high dose calcitonin group (112 U/ Kg), low dose calcitonin group (56 U/Kg), free calcitonin group, ovariectomy group, control group). To assess the pain in ovariectomized rats, the tail of rats were dived in waters of 50⁑1oC. Then the tail withdrawal time was measured (tail withdrawal test). The tail withdrawal test was performed in once a week for eight weeks.
Results
1. At seven and eight weeks after injection, the tail withdrawal time of high and low dose calcitonin group compared with that of ovariectomy group were significantly prolonged (p<0.05). 2. At eight weeks after injection, the tail withdrawal time of free calcitonin group compared with that of ovariectomy group was significantly prolonged (p<0.05).


Conclusion
The effect of calcitonin injection relieving pain in ovariectomized rats was found. (Korean Acad Rehab Med 2002; 26: 587-590)

Key Words: Ovariectomy, Calcitonin, Tail withdrawal test


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