The Change of Bone Metabolism in Stroke Rat.

, Park, Joo Hyun; , Ko, Young Jin; , Kim, Jong Hyun; , Lee, Jong In; , Shin, Ji Nam; , Lim, Seong Hoon; , Im, Sun

Original Article

Journal of the Korean Academy of Rehabilitation Medicine 2004;28(2):163-168.

Park, Joo Hyun , Ko, Young Jin , Kim, Jong Hyun , Lee, Jong In , Shin, Ji Nam , Lim, Seong Hoon , Im, Sun

¹Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Korea. seong-hoon@hanmail.net
²Department of Rehabilitation Medicine, College of Medicine, Cheju National University, Korea.

뇌경색 백서에서의 골대사 변화

박주현, 고영진, 김종현, 이종인, 신지남¹, 임성훈, 임선

가톨릭대학교 의과대학 재활의학교실, ¹제주대학교 의과대학 재활의학교실

Abstract

Objective
The purpose of this study was to investigate the effect of ischemic stroke on bone metabolism
Method
Female Sprague-Dawley rats (12 weeks old, n=48) were randomly divided into 4 separate groups; sham operation group (group A), stroke group (group B), ovariectomy group (group C), and stroke-ovariectomy group (group D). Two weeks after performing ovariectomy, cerebral ischemia was induced. The bone mineral density (BMD) and osteocalcin and carboxy-terminal telopeptide (CTX) were measured on three periods: the day before ischemia and 1 and 3 weeks post-stroke. All data were statistically analyzed.
Results
One week after cerebral ischemia, lumbar spine BMD of group B and D although statistically insignificantshowed a lower BMD score in comparison to group A and C, respectively. Three weeks after ischemia, compared to group C, the BMD score of lumbar spine in group D was reduced significantly (p＜0.05). At one week post-stroke, compared with group A and C, the value of osteocalcin in group B and D were reduced significantly, respectively (p＜0.05). One and three weeks after ischemia, the CTX value in all groups showed no statistical difference.
Conclusion
The authors concluded that ischemic stroke affected bone metabolism by decreasing osteoblastic activity in the early phase of stroke rat. (J Korean Acad Rehab Med 2004; 28: 163-168)

Key Words: Bone mineral density, Bone turnover marker, Osteoporosis, Rat model, Stroke