Mean Platelet Component Change according to Stage in Stroke Patients.

, Hong, Jun Hyoung; , Bok, Soo Kyung; , Jo, Kyung Ja; , Oh, Sang Hyang; , Yoon, Jong Myung; , Lee, Jongwook

Original Article

Journal of the Korean Academy of Rehabilitation Medicine 2005;29(1):32-37.

Hong, Jun Hyoung , Bok, Soo Kyung , Jo, Kyung Ja , Oh, Sang Hyang , Yoon, Jong Myung , Lee, Jongwook

Department of Rehabilitation Medicine, Konyang College of Medicine, 1Department of Laboratory Medicine, Konyang College of Medicine, Korea. pseudoj@medimail.co.kr

뇌졸중 환자의 시기에 따른 평균 혈소판 요소의 변화

홍준형, 복수경, 조경자, 오상향, 윤종명, 이종욱¹

건양대학교 의과대학 재활의학교실, ¹진단검사의학교실

Abstract

Objective
Decrease of platelet density by degranulation of activated platelet is well correlated with decrease of mean platelet component (MPC) value. We intended to investigate the change of MPC, mean platelet volume, and platelet count according to the stroke stage and difference between ischemic and hemorrhagic infarction.
Method
Thirty eight patients (ischemic stroke 28 men, hemorrhagic stroke 10 men) and twenty age-matched healthy persons were included in this study. They were divided into acute stage group and subacute stage group. Each of them were sampled by venously and investigated about mean platelet component, mean platelet volume, and platelet counts.
Results
In ischemic stroke, there was statically (p＜0.05) meaningful decrease of MPC value in acute stage (27.5⁑1.7) compared to control group (28.8⁑0.9). And MPC value in subacute stage showed meaningful increase (28.1⁑1.3) compared to acute stage but still remained in statically lower value compared to control value. In hemorrhagic stroke, there was no meaningful difference of MPC value in acute stage group (28.6⁑2.0) and subacute stage group (27.9⁑1.1) compared to control group.
Conclusion
In ischemic stroke patients, MPC value in acute stage decreased meaningfully and this change might be useful as a landmark in predicting the activity of infarction. (J Korean Acad Rehab Med 2005; 29: 32-37)

Key Words: Platelet activation, Mean platelet component, Stroke