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Journal of the Korean Academy of Rehabilitation Medicine 2005;29(5):513-520.
The Effect of Low-Level Laser Irradiation on Activities of Dorsal Horn Neurons in Rats with Experimental Muscle Pain.
Sohn, Min Kyun , Yoon, Yoe Sam , Lee, Sheng Huo , Kang, Sang Kuk , Kim, Bong Ok , Sohn, Jin Hoon
1Department of Rehabilitation Medicine, College of Medicine, Chungnam National University, Korea. mksohn@cnu.ac.kr
2Department of Psychology, College of Social Science, Chungnam National University, Korea.
3Institute for Brain Research, Chungnam National University, Korea.
4Dr. Yoon's Rehabilitation Medicine Clinic, Korea.
근육통 모델 쥐에서 저출력 레이저에 의한 척수후각신경세포의 활동 변화
손민균1,2, 윤여삼4, 이승활1,2, 강상국1,2, 김봉옥1,2, 손진훈2,3
충남대학교 1의과대학 재활의학교실, 2뇌과학연구소, 3사회과학대학 심리학과, 4윤재활의학과의원
This study was performed to investigate the effects of low-level laser irradiation on the dorsal horn cell activities in the rats with experimental muscle pain.
Experimental muscle pain was induced by repeated injections of acidic saline into the gastrocnemius muscle in thirty Sprague-Dawley rats. Activities of ipsilateral dorsal horn cells were recorded with a glass microelectrode at L2-L4 spinal cord level before and after low-level laser irradiation on the injected leg. Cells were categorized as wide dynamic range (WDR) and high threshold (HT) cells by the response to the cotton, vonFrey filament, and forceps stimulation at the receptive area.
The spontaneous and mechanically evoked activities of WDR and HT cells were significantly increased in the muscle pain models. Low-level laser irradiation reduced mechanically evoked activities of WDR and HT cells. This effect was maximal at 20 minutes after irradiation and then returned to pre-treatment level in 40∼50 minutes.
The low-level laser irradiation was effective for the management of muscle pain by reducing activities of dorsal horn cells. Low-level laser might be clinically used for the treatment of local and referred pain of muscle origin. (J Korean Acad Rehab Med 2005; 29: 513-520)
Key Words: Persistent muscle pain, Dorsal horn cell, Wide dynamic range cell, High threshold cell, Low-level laser


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