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Journal of the Korean Academy of Rehabilitation Medicine 2006;30(2):135-141.
Relevance of Behavioral Test in the Photothrombotic Stroke Rat Model.
Kim, Heon Soo , Shin, Yong Il , Kim, Hyoung Ihl , Moon, Seong Keun , Lee, Seoul , Moon, Byung Soon , Lee, Min Cheol
1Department of Rehabilitation Medicine, Wonkwang University School of Medicine, Korea. cbrmshin@wonkwang.ac.kr
2Department of Neurosurgery, Wonkwang University School of Medicine, Korea.
3Department of Pharmacology, Wonkwang University School of Medicine, Korea.
4Department of Neurosurgery, Presbyterian Medical Center, Korea.
5Department of Internal Medicine, Wonkwang University College of Oriental Medicine, Korea.
6Department of Pathology, Chonnam National University, School of Medicine, Korea.
광화학적 허혈성 뇌경색 쥐 모델에서 행동평가의 유용성
김헌수, 신용일, 김형일1, 문성근2, 이서울3, 문병순4, 이민철5
원광대학교 의과대학 재활의학교실, 2신경외과학교실, 3약리학교실, 1예수병원 신경외과

4원광대학교 한의학전문대학원 제3의학과, 5전남대학교 의과대학 병리학교실

The purpose of this study was to find reliable behavioral measures for the evaluation of motor dysfunction in photothrombotic ischemia rat model.
Male Sprague-Dawley rats were trained for behavioral test including tray reaching task (TRT), single pellet reaching task (SPRT), and rotarod task (RRT) for more than 2 weeks. Photothrombotic ischemia was induced in a stereotactically held rats using Rose Bengal dye (20 mg/kg) and cold light. Rats were assigned to either control (n=10) or experimental ischemic group (n=10). Post-lesional behavioral tests were performed for 4 weeks after confirma-tion of lesion by magnetic resonance imaging (MRI), followed by histological examination.
RRT showed no difference between control and experimental group. SPRT and TRT showed significant difference between control and experimental group (p<0.05). SPRT could well demonstrate the recovery of motor dysfunction after over time.
SPRT could be the most reliable test to measure not only motor dysfunction but also motor recovery in unilateral motor cortex lesion of photothrombotic ischemia rat model. (J Korean Acad Rehab Med 2006; 30: 135-141)
Key Words: Stroke, Thrombosis, Behavior, Rat


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