• KARM
  • Contact us
  • E-Submission
ABOUT
ARTICLE TYPES
BROWSE ARTICLES
AUTHOR INFORMATION

Articles

Original Article

Therapeutic Effect according to Estrogen Dosage on Combined Therapy with Estrogen and Alendronate in Postmenopausal Osteoporosis.

Kim, Ghi Chan , Jeong, Ho Joong , Ha, Ho Sung , Lee, Sang Jin
Journal of the Korean Academy of Rehabilitation Medicine 2006;30(3):247-253.
1Department of Physical Medicine & Rehabilitation, Kosin University College of Medicine, Korea. hhs96a@hanmail.net
2Dong-eui Hospital, Korea.
  • 1,520 Views
  • 8 Download
  • 0 Crossref
  • 0 Scopus
prev next

Objective
To compare the difference of bone mineral density (BMD), biochemical markers, and lipid profiles according to dosage of estrogen on combined therapy with estrogen and alendronate in postmenopausal osteoporosis. Method: We studied 81 women with postmenopausal osteoporosis (T-score<2.5) from March 2002 to February 2005. Subjects were divided in two groups; Group I (n=36), treated with low dose hormone therapy (HT) (0.3 mg estrogen/1.25 mg MPA (Medroxyprogesterone acetate)) and alendronate, and Group II (n=45), treated with standard dose HT (0.625 mg estrogen/2.5 mg MPA) and alendronate. BMD at the L-spine and femur, osteocalcin, deoxypyridinoline, and lipid profiles were measured at baseline and 1 year after treatment.Results: BMD at the L-spine increased significantly in two groups and BMD at the femur increased but showed no statistical differences. Deoxypyridinoline and osteocalcin decreased significantly in two group. Total cholesterol and LDL (low density lipoprotein) cholesterol decreased significantly in two groups, no significant difference was observed between two groups in BMD, osteocalcin, deoxypyridinoline, and lipid profiles. Conclusion: We concluded that combined therapy with low dose estrogen and alendronate in postmenopausal osteoporosis showed similar therapeutic effect provied by combined therapy of standard dose estrogen and alendronate. (J Korean Acad Rehab Med 2006; 30: 247-253)

TOP