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Journal of the Korean Academy of Rehabilitation Medicine 2007;31(6):762-766.
The Combination Therapy of Low Dose Estrogen and Fluoride (Monofluorophosphate) for 2 Years in Postmenopausal Women with Osteopenia.
Kim, Ghi Chan , Jeong, Ho Joong
Department of Physical Medicine and Rehabilitation, Kosin University College of Medicine, Korea. ghckim@hanmail.net
골감소증을 가진 폐경여성에서 저용량 에스트로겐과 불소의 2년 치료
김기찬, 정호중
고신대학교 의과대학 재활의학교실
To investigate the changes of BMD (bone mineral density), biochemical bone markers and lipid profiles after combination therapy of low dose estrogen (0.3 mg) and intermittent fluoride (monofluorophosphate) in postmenopausal osteopenia.
We studied 61 women with postmenopausal osteopenia from March 2002 to May 2005. Group I (n=30) was treated with low dose estrogen (0.3 mg), fluocalcic(monofluorophosphate 100 mg+calcium 500 mg), and calcium (500 mg). Group II (n=31) was treated with standard dose estrogen (0.625 mg) and calcium (1,000 mg). BMD at the lumbar spine and femur, osteocalcin, deoxypyridinoline, and lipid profiles were measured at baseline and 2-year after treatment.
1) Average postmenopausal periods were 2.8 years and 3.1 years in Group I and II, respectively. 2) BMD increased significantly in two groups, and BMD in group I increased significantly more than that in group II. 3) Deoxypyridinoline decreased significantly in two groups, and there was no significant difference between the two groups. 4) Total cholesterol and LDL cholesterol decreased significantly in two groups.
Combination therapy with monofluorophosphate and low dose estrogen in postmenopausal osteopenia was more effective than standard dose estrogen therapy to prevent postmenopausal osteoporosis. (J Korean Acad Rehab Med 2007; 31: 762-766)
Key Words: Postmenopausal osteopenia, Monofluorophosphate, Low dose estrogen, Bone mineral density


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