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Journal of the Korean Academy of Rehabilitation Medicine 2006;30(4):333-339.
Neuroprotective Effect of Exogenous Growth Hormone in Brain Injury-Rat Model.
Yang, Hee Seung , Chun, Min Ho , Kim, Don Kyu , Kim, Sang Tae , Jo, Hee Jin
1Department of Rehabilitation Medicine, Soonchunhyang University College of Medicine, Korea.
2Department of Rehabilitation Medicine, University of Ulsan College of Medicine, Korea. mhchun@amc.seoul.kr
3Department of Rehabilitation Medicine, Chungang University College of Medicine, Korea.
4Nucleomagnetic Resonance Laboratory, Asan Institute for Life Sciences, Korea.
뇌손상 백서 모델에서의 성장호르몬의 뇌 보호 효과
양희승, 전민호1, 김돈규2, 김상태3, 조희진3
순천향대학교 의과대학 재활의학교실, 1울산대학교 의과대학 재활의학교실, 2중앙대학교 의과대학 재활의학교실, 3아산생명과학 연구소
Abstract
Objective
To evaluate the neuroprotective effect of growth hormone (GH) following lateral fluid percussion brain injury.
Method
Sprague-Dawley rats weighing 200∼250 g were subjected to moderate lateral fluid percussion brain injury and evaluated at 1, 7, 14 and 28 days post-injury. Rats were divided into control and GH pretreatment groups. GH (10 μg/10μl) or normal saline (10μg/10μl) was administered by intracerebro-ventricular injection 30 min before brain injury. We measured histopathological changes with TUNEL and toluidine blue Nissl stain and conducted motor function tests and an 8-arm radial maze test to identify neurobehavioral deficits and cognitive deficits, respectively, at oneday to 4 weeks post-injury.
Results
In the pretreated GH group, a significant reduction in TUNEL-positive cells was found compared with the control group at 1 day and 1 week post-injury (p<0.05). The pretreated GH group showed significantly greater improvement than controls motor function tests at 1 day post-injury (p<0.05) and in an 8-arm radial maze test at 2 and 4 weeks post-injury (p<0.05).
Conclusion
These findings suggested that GH had a neuroprotective effect in neuronal cell death, motor function and cognitive deficits following experimental brain injury. (J Korean Acad Rehab Med 2006; 30: 333-339)
Key Words: Growth hormone, Traumatic brain injury, Motor function test, Maze test


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