Motor Recovery Effect of Minocycline in Spinal Cord Injured Rats.

, Ko, Hyun Yoon; , Chang, Jae Hyeok; , Park, Jae Heung

Original Article

Journal of the Korean Academy of Rehabilitation Medicine 2006;30(6):565-570.

Ko, Hyun Yoon , Chang, Jae Hyeok , Park, Jae Heung

Department of Rehabilitation Medicine, Pusan National University College of Medicine, Korea. kulu73@medimail.co.kr

척수손상 쥐에서 미노사이클린에 의한 운동기능 회복 효과

고현윤, 장재혁, 박재흥

부산대학교 의과대학 재활의학교실

Abstract

Objective
To observe motor recovery after spinal cord injury (SCI) by time and impact strength in minocycline administration rat.
Method
Forty Sprague-Dawley rats were divided into four groups according to minocycline administration and damage heights. Rats in first group were damaged in 2.5 cm heights, and injected with minocycline. In second group, minocycline was not injected. Rats in third group were damaged in 5 cm heights, and injected with minocycline. In fourth group, rats were damaged in 5 cm and minocycline was not injected. Rats received injury by the force-calibrated weight drop device and first and third groups injected minocycline 90 mg/kg immediately after injury and injected 45 mg/kgevery 12 hours. Motor recovery was determined by the Basso-Beattie-Bresnahan (BBB) locomotor rating scale at 1st, 7th, 14th, 21st, and 28th day after injury.
Results
The BBB scores were significantly higher in first and third groups as compared to second and fourth groups after injury. There was significant change of BBB scores in first group as compared to third.
Conclusion
After injury, BBB scores were significantly higher in minocycline treated rats as compared to the control. Minocycline might have beneficial effects on the recovery cascade after SCI. (J Korean Acad Rehab Med 2006; 30: 565-570)

Key Words: Minocycline, Spinal cord injury, Weight drop device, Basso-Beattie-Bresnahan scores