Multiple sclerosis is a scattered inflammatory and demyelinating lesion of central nervous system, which reveals various symptoms and signs of motor, sensory, coordination, and cognitive impairments. The etiology and pathology of multiple sclerosis is unknown and clinical symptoms and course are various, for that reason single symptom, sign or laboratory abnormality, radiologic imaging is nonspecific for the diagnosis of multiple sclerosis. To ensure the clinically definite diagnosis it should be based on review of history, clinical sympmtoms, signs, neurologic examination, supportive of laboratory evidence, paraclinical evidence, and differential diagnosis is must beneeded.

The Schumacher classification of multiple sclerosis is divided to clinically definite, probable, possible. Clinically definite multiple sclerosis is objective CNS(central nervous system) dysfunction, two or more sites of CNS involvement, predominantly white matter involvement, relapsing-remiting or chronic(more than months) progressive course, age 10 to 50 years at on set, and no better explanation of symptoms.

We experienced 1 case of multiple sclerosis, which shows clinically definite finding and reported the case with physical examination, laboratory evidence, evoked potential, electromyelography, magnetic resonance imaging.