The purpose of this study was to know what changes in serum beta-endorphin level indirectly as low frequency TENS was applied to the meridian and non-meridian points.

The results were as follows:

1) On applying TENS to the meridian and non-meridian point, the mean changed values of the ACTH were 9.17±3.78, 11.41±7.31, 5.28±4.87 pg/ml and 7.57±2.37, -3.18±2.16, -7.22±3.57 pg/ml respectively at 15, 30, 60 minute after the TENS was applied.

2) The mean changed values of the ACTH were not statistically signficant(p>0.05) at 15, 30 minute, but statistically significant(0.05) at 60 minute after the TENS was applied.

3) on applying TENS to the meridian and non-meridian points the mean changed values of the Cortisol were 8.07±1.93, 7.13±1.20, 4.32±1,37 ㎍/100ml and 4.96㎍1.41, 2.97±1.25, -0.84±1.16 ㎍/100ml respectively at 15, 30, 60 minute after the TENS was applied.

4) The mean changed values of the Cortisol were not statistically significant(p>0.05) at 15 minute but statistically significant(p<0.05) at 30, 60 minute after the TENS was applied.

We concluded that the analgesic effect by the stimulation is related to nervous system and humoral factor such as the neurotransmitter and the hormone.