Baclofen(B-4-chlorphyl-r-amino butyric acid), a centrally acting gamma amino butyric acid(GABA) agonist is a commonly used pharmaceutics for spasticity of spinal cord lesion. It's effect includes activation of GABA receptor in primary sensory afferent, enhancement of Ranshow cell activity and depression of fusimotor response. It is primarily excreted by glomerullar filtration with a clearance proportional to creatinine clearance. It's popularity is a result of the antispastic effects and the lack of toxic effect on organ. But, transient drowsiness is the most common neurological side effect with therapeutic dose of this drugs. We report here two patients who developed an acute side effects after being treated with relative therapeutic dose of baclofen.
