Adverse Side Effect of Baclofen: Case Report. |
Kim, Dong Yen , Choi, Sun Mi , Kim, Young Seom , Oh, Seung Hyun , Lee, Jin |
Department of Rehabilitation Medicine, Presbyterian Medical Center, Chonju, Korea. |
Baclofen 사용에 의한 부작용 -증례 보고- |
김동연, 최선미, 김영섬, 오승현, 이진 |
전주 예수병원 재활의학과학교실 |
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Abstract |
Baclofen(B-4-chlorphyl-r-amino butyric acid), a centrally acting gamma amino butyric acid(GABA) agonist is a commonly used pharmaceutics for spasticity of spinal cord lesion. It's effect includes activation of GABA receptor in primary sensory afferent, enhancement of Ranshow cell activity and depression of fusimotor response. It is primarily excreted by glomerullar filtration with a clearance proportional to creatinine clearance. It's popularity is a result of the antispastic effects and the lack of toxic effect on organ. But, transient drowsiness is the most common neurological side effect with therapeutic dose of this drugs. We report here two patients who developed an acute side effects after being treated with relative therapeutic dose of baclofen. |
Key Words:
Spasticity, Baclofen, Side effect |
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