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Journal of the Korean Academy of Rehabilitation Medicine 1998;22(1):93-99.
The Biochemical Bone Marker of the Pre and Postmenopausal Osteoporotic Women.
Mun, Ki Hyun , Kim, Chang Pyo , Kang, Bong Goo , Lee, Yang Gyun
Department of Rehabilitation Medicine, Soonchunhyang University, Collage of Medicine.
폐경후 골다공증에서 생화학적 골대사지표
문기현, 김창표, 강봉구, 이양균
순천향대학교 의과대학 재활의학교실

The main objectives of this study were to assess the age related changes of biochemical indices of bone turnover in postmenopausal osteoporotic females, and to assess the correlations of these indices with bone mineral density(BMD) of lumbar spine measured by dual energy X-ray absorptiometry(DEXA). Subgects were 70 osteoporotic women in pre and postmenopausal periods. The results showed that Postmenopausal women had higher level of Osteocalcin(OS) and Deoxypyridinoline(DPYD) with lower level BMD of lumbar spine compared with premenopausal women. Age, height, and weight had significant correlations with BMD of lumbar spine. Also a significant correlation was observed between the OS and DPYD. Pre and postmenopausal osteoporotic women(5, 10, 15 year duration) were similar for the rate of bone turnover. These results indicate that the biochemical indices used in our study are the potential markers to predict an age related change of BMD, as well as bone turnover rate of the lower BMD subjects. The combination of BMD measurement and assessment of the bone turnover rate by measuring biochemical indices would be helpful for the screening and treatment of patients with risks of osteoporosis.

Key Words: Osteocalcin, Deoxypyridinoline, Bone mineral density, Bone turnover rate


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