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Journal of the Korean Academy of Rehabilitation Medicine 2000;24(2):175-178.
Histological Changes of the Intervertebral Disc with Intradiscal Steroid Injection.
Ko, Hyun Yoon , Sol, Mee Young , Shin, Yong Beom , Park, Jae Heung
1Department of Rehabilitation Medicine, Pusan National University College of Medicine.
2Department of Pathology, Pusan National University College of Medicine.
추간판 내 스테로이드 주입에 의한 추간판의 조직학적 변화
고현윤, 설미영1, 신용범, 박재흥
부산대학교 의과대학 재활의학교실, 1병리학교실

To observe histological changes of the intervertebral disc injected with intradiscal steroid and mollification of discogenic pain.

A study group of 25 Sprague-Dawely rats was divided into five subgroups. A control group of 10 Sprague-Dawely rats was divided into five subgroups. The rats' intervertebral discs were exposed by an anterior surgical approach. For study group, the rats were injected intradiscally methylprednisolone acetate 4 mg (Depomedrol, 40 mg/ml) to the L4-L5 intervertebral disc, methylprednisolone sodium succinate 4 mg (Solumedrol, 40 mg/ml) to the L5-L6 intervertebral disc, and triamcinolone acetonide 4 mg (Triamcinolone, 40 mg/ml) to the L6-S1 intervertebral disc. For control group, the rats were injected intradiscally 0.1 ml of saline to the L5-L6 intervertebral disc and a needle was inserted in the L6-S1 intervertebral disc. The intervertebral discs were extracted after 1 week, 2 weeks, 3 weeks, 4 weeks, and 16 weeks. The extracted intervertebral discs were stained with Hematoxylin-Eosin and examined histomorphometrically.

There is no significant histological change in either group until 4 weeks after the different types of steroid were injected. Focal fibrotic change was present in the Solumedrol and Triamcinolone injection subgroups after 16 weeks.

We concluded that rapid mollification of discogenic pain following intradiscal steroid injection may not result from histological change of the disc. Further biochemical study will be neccessary to clarify mollification mechanism of discogenic pain by intradiscal steroid injection.

Key Words: Intradiscal steroid injection, Discogenic pain, Histological change


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