Effects of Dexamethasone on Neurogenic Bladder in Experimental Autoimmune Encephalomyelitis Rat. |
Park, Joo Hyun , Ko, Young Jin , Choi, Eun Seok , Kim, Hye Won , Kim, Jong Hyun , Park, Se Hoon |
Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea. medipsh@hanmail.net |
실험적 자가 면역 뇌척수염 쥐의 신경인성 방광에 대한 덱사메타손의 효과 |
박주현, 고영진, 최은석, 김혜원, 김종현, 박세훈 |
가톨릭대학교 의과대학 재활의학교실 |
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Abstract |
Objective We studied effects of dexamethasone on neurogenic bladder and paralysis in experimental autoimmune encephalomyelitis (EAE) rat model for multiple sclerosis. Method Thirty-five female Lewis rats were used in the study. Thirteen rats used as normal cystometrogram controls. Twenty-two rats induced EAE were divided into two groups: ten rats as control and twelve rats as dexamethasone injection group. Bladder dysfunction by cystometrogram, severity of weakness, and duration of paralysis were evaluated every other day after the onset of paralysis.
Results Dexamethasone injection group compared to control group presented short duration of bladder dysfunction (2.5 vs. 4.2 day, p<0.05) and paralysis (4.5 vs. 7.3 day, p<0.05). There was a trend for lesser paralysis in the dexamethasone injection group, than control group (weakness scores were 2.4 vs. 3.6, p>0.05), but it was not statistically significant.
Conclusion Dexamethasone ameliorates the course of paralysis and bladder dysfunction in EAE. We suggest that dexamethasone treatment is an effective method in treating neurogenic bladder and paralysis in multiple sclerosis.
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Key Words:
Experimental autoimmune encephalomyelitis (EAE), Multiple sclerosis, |
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