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Journal of the Korean Academy of Rehabilitation Medicine 2003;27(5):682-687.
Effects of Dexamethasone on Neurogenic Bladder in Experimental Autoimmune Encephalomyelitis Rat.
Park, Joo Hyun , Ko, Young Jin , Choi, Eun Seok , Kim, Hye Won , Kim, Jong Hyun , Park, Se Hoon
Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea. medipsh@hanmail.net
실험적 자가 면역 뇌척수염 쥐의 신경인성 방광에 대한 덱사메타손의 효과
박주현, 고영진, 최은석, 김혜원, 김종현, 박세훈
가톨릭대학교 의과대학 재활의학교실
We studied effects of dexamethasone on neurogenic bladder and paralysis in experimental autoimmune encephalomyelitis (EAE) rat model for multiple sclerosis.

Thirty-five female Lewis rats were used in the study. Thirteen rats used as normal cystometrogram controls. Twenty-two rats induced EAE were divided into two groups: ten rats as control and twelve rats as dexamethasone injection group. Bladder dysfunction by cystometrogram, severity of weakness, and duration of paralysis were evaluated every other day after the onset of paralysis.

Dexamethasone injection group compared to control group presented short duration of bladder dysfunction (2.5 vs. 4.2 day, p<0.05) and paralysis (4.5 vs. 7.3 day, p<0.05). There was a trend for lesser paralysis in the dexamethasone injection group, than control group (weakness scores were 2.4 vs. 3.6, p>0.05), but it was not statistically significant.

Dexamethasone ameliorates the course of paralysis and bladder dysfunction in EAE. We suggest that dexamethasone treatment is an effective method in treating neurogenic bladder and paralysis in multiple sclerosis.

Key Words: Experimental autoimmune encephalomyelitis (EAE), Multiple sclerosis,


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