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Journal of the Korean Academy of Rehabilitation Medicine 2005;29(2):177-180.
Neurodevelopmental Outcome in Children Born after in vitro Fertilization.
Na, Hyo Jin , Sung, In Young , Choi, Kyoung Hyo , Kim, Chung Hoon
1Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Korea. jysung@amc.seoul.kr
2Department of Obstetric and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Korea.
체외수정 시술로 출생한 어린이의 신경발달학적 예후
나효진, 성인영, 최경효, 김정훈1
울산대학교 의과대학 서울아산병원 재활의학교실, 1산부인과학교실
To investigate neurodevelopmental long-term outcome in children born after in-vitro fertilization (IVF).
We performed retrospective study in which we investigated development of neurodevelopmental disability in 254 childern (113 twins, 28 singletons) born after in vitro fertilization between Janurary 1995 and December 1999. We obtained neurodevelopmental status on a certain date and disability of children from medical records or phone interviews of parents. We assessed developmental status, congenital malformation, cerebral palsy and seizure, speech disorder, other neurologic problems, prematurity, low birth weight, maternal age, intraventricular hemorrhage (IVH), retinopathy and congenital anomaly.
Six children (2.3%) were diagnosed as cerebral palsy, three children (1.2%) as developmental delay and 11 had IVH, 6 had retinopathy, 10 had congenital anomaly (esp. abdominal wall defect). The mean maternal age was 30⁑2.8 years old and gestational age was 35⁑3.0 weeks. One hundred one children (39.7%) were born prematurely, 66.5% low birth weight.
High prevalence of neurodevelopmental disabilities like cerebral palsy compared to population controls (cerebral palsy: 1.9/1000 live birth) was revealed. Therefore, we should know mild high risk of developmental disability and do developmental examination carefully in children born after IVF and long-term follow up. (J Korean Acad Rehab Med 2005; 29: 177-180)
Key Words: In-vitro fertilization, Developmental disability, Cerebral palsy, Prematurity, Low birth weight


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