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Journal of the Korean Academy of Rehabilitation Medicine 2005;29(4):351-358.
Functional Status and Blood Level of IGF-1 and IGFBP-3 in Post-acute Stage Brain Diseases.
Choi, Deok Hyung , Han, Tai Ryoon , Kim, Dai Youl , Lee, Si Wook , Yoon, Kyung Jae , Kim, Jae Ho , Lim, Sung Hun
1Department of Rehabilitation Medicine, Seoul National University College of Medicine. tairyoon@snu.ac.kr
2Department of Rehabilitation Medicine, Boramae Hospital, Seoul National University College of Medicine.
3Department of Rehabilitation Medicine, Seoul Medical Center.
급성기 이후 뇌질환 환자의 IGF-1 및 IGFBP-3와 기능적 수준
최덕형, 한태륜, 김대열1, 이시욱1, 윤경재2, 김재호, 임성훈
서울대학교 의과대학 재활의학교실, 1보라매병원 재활의학과, 2서울의료원 재활의학과
Abstract
Objective
To evaluate the blood level of IGF-1 (insulin- like growth factor-1) and IGFBP-3 (insulin-like growth factor binding protein-3) in patients with post-acute stage brain diseases, and to investigate the relationship between IGF-1/ IGFBP-3 blood level and functional status in patients with post-acute stage brain diseases.
Method
Initial IGF-1/IGFBP-3 blood levels of 32 patients with post-acute stage brain disease were obtained and various functional indices, including modified Barthel index (MBI), functional ambulatory category (FAC), and Jebsen hand function test (JHFT), were assessed initially and at discharge.
Results
The IGF-1 blood level was normal in 23 patients and decreased in 9. The IGFBP-3 blood level was normal in 20 patients and increased in 13. The initial IGF-1/IGFBP- 3 levels were associated with the change of MBI score during admission (p<0.05, r2=0.214/p<0.05, r2=0.213). There was a correlation between IGF-1/IGFBP-3 levels and JHFT score only on the unaffected side at discharge (p<0.05, r2=0.278). There was no relation between IGF-1/IGFBP-3 levels and the change of JHFT score on either side during admission.
Conclusion
Initial IGF-1/IGFBP-3 blood level check can be a useful method to anticipate functional improvement of patients with post-acute stage brain disease. (J Korean Acad Rehab Med 2005; 29: 351-358)
Key Words: IGF-1, IGFBP-3, Functional improvement
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