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Journal of the Korean Academy of Rehabilitation Medicine 2006;30(4):322-327.
The Findings of 1H Magnetic Resonance Spectroscopy in Children with Mental Retardation or Autism.
Lee, Jung Hwan , Sung, In Young , Kim, Ki Soo , Kim, Sang Tae , Lee, Jung Hee
1Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Korea. iysung@www.amc.seoul.kr
2Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Korea.
3Department of Nuclear Magnetic Resonance, Asan Institute for Life Sciences, Korea.
4Department of Radiology, Sungkyunkwan University School of Medicine, Korea.
정신지체 아동과 자폐 아동에서의 수소 자기 공명 분광 소견
이정환, 성인영, 김기수1, 김상태2, 이정희3
울산대학교 의과대학 서울아산병원 재활의학과, 1소아과, 2아산생명과학연구소 자기공명연구실, 3성균관대학교 의과대학 서울삼성병원 진단방사선과
To investigate the findings of patients with autism or mental retardation shown in 1H magnetic resonance spectroscopy (1H MRS) and the correlation between findings in 1H MRS and degree of language developmental delay.
1H MRS was performed in thirty five patients with autism or mental retardation. [N-Acetylaspartate (NAA)/ Creatine (Cr)], [Choline (Cho)/Cr], and [Myoinositol (mI)/ Cr] were measured and compared with those of control group. Also the correlation between 1H MRS findings and the degree of language developmental delay was investigated.
Increased [Cho/Cr] was shown in parietal white matter and frontal gray matter in patients with autism and mental retardation. No significant differences were revealed in any metabolite ratio between mental retardation and autism. There were no significant correlations between the degree of language developmental delay and metabolite ratios.
Myelin degeneration in parietal white matter and fronal gray matter could be related to autism and mental retardation. (J Korean Acad Rehab Med 2006; 30: 322- 327)
Key Words: Magnetic resonance spectroscopy, Autism, Mental retardation, Language


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