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Journal of the Korean Academy of Rehabilitation Medicine 2007;31(3):278-282.
Improvement of Apraxia and Hand Function with Transcranial Direct Current Brain Polarization in Patients with Corticobasal Degeneration.
Ko, Myoung Hwan , Wassermann, Eric M , Seo, Jeong Hwan , Kim, Yun Hee
1Department of Physical Medicine and Rehabilitation, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Korea. mhko@chonbuk.ac.kr
2National Institutes of Health, USA.
3Department of Physical Medicine and Rehabilitation, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.
피질기저핵변성 환자에서 경두개 직류전류 자극 후 실행증 및 손기능 호전
고명환, EricM.Wassermann1, 서정환, 김연희2
전북대학교 의과대학 재활의학교실 및 임상의학연구소, 1미국 국립보건원, 2성균관대학교 의과대학 삼성서울병원 재활의학교실
To see whether anodal direct current (DC) polarization of the inferior parietal cortex (IPC) and the primary sensorimotor area (SM1) in corticobasal degeneration (CBD) patients leads to improvement of praxia and finger motion.
Twelve patients with CBD were enrolled. This single blind crossover study had three arms, anodal DC to IPC, anodal DC to SM1, and shame polarization on occipital area. DC was delivered for 40 minute at 2 mA with 25 cm2 sponge electrodes. Before and 20 min after the start of polarization, we performed the test of oral and limb apraxia (TOLA), finger tapping frequency, and grooved pegboard test.
The total score of TOLA was increased 5.4±2.3% after anodal DC to IPC. The scores of limb apraxia and picture gesture subtests of TOLA, not of oral apraxia subtest, increased significantly after anodal DC to IPC compared to sham DC polarization (p<0.05). In anodal DC to SM1 group, the finger tapping frequency increased 15.5±14.1%, which was significantly greater than in sham group (p<0.05).
These results showed beneficial effects of anodal DC polarization on apraxia and hand function in CBD patients. In addition, these effects for apraxia and hand movement were dependent on their stimulation sites of brain. (J Korean Acad Rehab Med 2007; 31: 278-282)
Key Words: Transcranial direct current stimulation, Brain polarization, Apraxia, Hand function, Corticobasal degeneration


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