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Journal of the Korean Academy of Rehabilitation Medicine 2007;31(5):516-520.
Usefulness of 1H Magnetic Resonance Spectroscopy for Evaluation of Cognitive Impairment after Subarachnoid Hemorrhage Caused by Rupture of Middle Cerebral Artery Aneurysm.
Kang, Si Hyun , Chun, Min Ho , Na, Hyo Jin , Kim, Sang Tae
1Department of Rehabilitation Medicine, Chung-Ang University College of Medicine, Korea.
2Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Korea. mhchun@amc.seoul.kr
3NMR Laboratory, ASAN Institute of Life Sciences, Asan Medical Center, Korea.
중뇌 동맥 꽈리동맥류 파열에 의한 지주막하출혈 후의 인지저하 평가에 있어 수소자기공명분광법의 유용성
강시현1, 전민호2, 나효진2, 김상태3
1중앙대학교 의과대학 재활의학교실, 2울산대학교 의과대학 서울아산병원 재활의학교실, 3서울아산병원 아산생명과학연구소 자기공명연구실
Abstract
Objective
To investigate the relationship between cognitive impairment and 1H magnetic resonance spectroscopy (1H MR spectroscopy) in patients with subarachnoid hemorrhage (SAH) caused by rupture of middle cerebral artery (MCA) aneurysm.
Method
1H MR spectroscopy was performed in 6 patients with SAH after rupture of MCA aneurysm and in 20 controls. Image-guided localized 1H MR spectra were obtained from left parietal white matter (PWM). The cognitive status was evaluated using the Mini Mental Status Examination (MMSE), and the scores were correlated with N- acetyl aspartate/creatine (NAA/Cr), choline/creatine (Cho/ Cr), and myoinositol/creatine (mI/Cr) metabolic ratios.
Results
NAA/Cr was significantly lower, and Cho/Cr was higher in SAH patients than in controls in the left PWM (p<0.05). NAA/Cr in the left PWM was correlated with MMSE (p<0.05), but Cho/Cr and mI/Cr in the left PWM was not correlated with MMSE (p>0.05).
Conclusion
1H MR spectroscopy could be helpful in the evaluation of cognitive impairment in SAH. (J Korean Acad Rehab Med 2007; 31: 516-520)
Key Words: Subarachnoid hemorrhage, Cognitive impairment, Neurological outcome, Mini Mental State Examination, 1H magnetic resonance spectroscopy
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