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Journal of the Korean Academy of Rehabilitation Medicine 2007;31(5):596-601.
Hypoglycemia-induced Dementia and MR Image-irreversible Restricted Diffusion in Splenium of Corpus Callosum: A case report.
Chae, Yu Jin , Kim, Min Young , Moon, Ja Yung , Kim, Sung Hyun , Kim, Sang Hum , Lee, Jae Hyuk , Lee, Do Youn
1Department of Rehabilitation Medicine, Pochon Cha University College of Medicine, Korea. kmin@cha.ac.kr
2Department of Radiology, Pochon Cha University College of Medicine, Korea.
3Department of Rehabilitation Medicine, Psychology Counselling, Bundang Cha Hospital, Korea.
저혈당으로 인한 치매와 뇌 영상에서의 비가역적 손상 -증례 보고-
채유진, 김민영, 문자영, 김성현, 김상흠1, 이재혁, 이도연2
포천중문의과대학교 재활의학교실, 1영상의학교실, 2분당차병원 재활의학과 심리치료실
The clinical impact of severe hypoglycemic brain insult is ranged from alterations of mental status to profound coma and death. However, the exact mechanism of hypoglycemic brain insult is not well known yet. We report a case of a 75-year-old female with diabetes, who developed dementia after a severe hypoglycemic event. Diffusion-weighted magnetic resonance imaging detected an increased signal intensity in the splenium of corpus callosum. After 6 days, follow-up MRI (T2 weighted imaging) revealed irreversible signal abnormalities in the splenium of corpus callosum. Also, SPECT (Single Positron Emission Computed Tomography) and PET (Positron Emission Tomography) revealed decreased cerebral functions in left parietal, temporal and occipital lobes. This case brings up better understanding for the extent and mechanism of hypoglycemic brain insult. (J Korean Acad Rehab Med 2007; 31: 596-601)
Key Words: Hypoglycemia, Brain injury, Dementia
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