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Journal of the Korean Academy of Rehabilitation Medicine 2010;34(1):1-9.
Effects of Enriched Environment on Locomotion and Cognition in Neonatal Rats with Hypoxic-Ischemic Encephalopathy.
Yang, Shin Seung , Sohn, Min Kyun , Kim, Bong Ok , Choi, Pil Soon , Kim, Sung Gyum
1Department of Rehabilitation Medicine, College of Medicine, Brain Research Institute, Chungnam National University, Korea. mksohn@cnu.ac.kr
2Sun-lin Rehabilitation Hospital, Korea.
저산소 뇌허혈 백서에서 풍요한 환경이 운동과 인지 발달에 미치는 영향
양신승1, 손민균, 김봉옥, 최필순, 김성겸
충남대학교 의과대학 재활의학교실, 뇌과학연구소, 1선린재활요양병원
Abstract
Objective
To investigate the effect of environmental enrichment on the cognitive and motor development in the experimental hypoxia-ischemic encephalopathy neonatal rat model.
Method
Hypoxic-ischemic encephalopathy models were made in neonatal Sprague-Dawley rats at 3 days of age by ligating the unilateral carotid artery followed by inhalation of 8% oxygen and raised in the enriched environment (n=10), treadmill exercise (n=8) and non-stimulation (n=10) from the 3rd to 8th weeks of age. Neurobehavioral and histopathological changes were compared.
Results
The neurobehavioral tests of the rats with hypoxic- ischemic encephalopathy showed prolonged latencies of achievement for cliff avoidance and negative geotaxis (p<0.05). Persisting abnormality into adult life of limb placing improved in exercise and enriched environment groups and spatial learning and memory in a water maze recovered in the rats with enriched environment (p<0.05). The density of dendritic spine increased in the hippocampus with enriched environment (p<0.05).
Conclusion
The present study supports the possibilities of the positive effects after the enriched environment in the developing brain with hypoxic injury. (J Korean Acad Rehab Med 2010; 34: 1-9)
Key Words: Enriched environment, Hypoxic-ischemic encephalopathy, Neonate, Rat


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