1Department of Physical Medicine and Rehabilitation, Vanderbilt University School of Medicine, Nashville, TN, USA.
2Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul, Korea.
3Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
4Department of Physiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
Corresponding author: Walter R. Frontera. Department of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Suite 1318, 2201 Children's Way, Nashville, TN 37212, USA. Tel: +1-615-322-7574, Fax: +1-615-327-9289, walter.frontera@vanderbilt.edu
• Received: March 13, 2015 • Accepted: March 26, 2015
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Aging has become an important topic for scientific research because life expectancy and the number of men and women in older age groups have increased dramatically in the last century. This is true in most countries of the world including the Republic of Korea and the United States. From a rehabilitation perspective, the most important associated issue is a progressive decline in functional capacity and independence. Sarcopenia is partly responsible for this decline. Many changes underlying the loss of muscle mass and force-generating capacity of skeletal muscle can be understood at the cellular and molecular levels. Muscle size and architecture are both altered with advanced adult age. Further, changes in myofibers include impairments in several physiological domains including muscle fiber activation, excitation-contraction coupling, actin-myosin cross-bridge interaction, energy production, and repair and regeneration. A thorough understanding of these alterations can lead to the design of improved preventative and rehabilitative interventions, such as personalized exercise training programs.
By 2050, the world's population over 60 years will double from about 11% to 22% and there will be 2 billion people aged 60 or older living on this planet. Approximately 400 million will be 80 years or older [1]. Further, by 2050, 80% of older people will live in low- and middle-income countries. This increase in the number of people in older age groups is associated with an increase in life expectancy. For example, in 2012 in South Korea, life expectancy was 81.4 years (84.8 for women and 78.1 for men), which puts South Korea in 14th place among 182 countries in the world (Fig. 1). For comparison purposes it is worth noting that, during the same year, life expectancy in the United States was 78.7 years [2].
The increase in the number of people in older age groups, per se, should not be considered a problem. However, aging is associated with an increased incidence of chronic health conditions and, perhaps more importantly, with an increase prevalence of impairment and disability. Visual and hearing impairments, cognitive decline, musculoskeletal disorders, frailty, and sarcopenia all reduce activity and restrict participation in personal, work-associated, and social activities. As a consequence, it has been estimated that, the number of older people requiring long-term care due to loss of functional independence will quadruple by 2050 [1].
Functional changes in elderly
Aging is associated with changes in body composition (increase in body fat and decreases in muscle and bone mass) which together with a decline in cognitive, visual, and hearing function, sleeping disorders, depression, and increased fatigue lead to a decline in physical function and significantly increases the risk for disability and loss of independence [3].
The prevalence of mobility limitations in elderly is high and is associated with frequent transitions between independent and dependent states. Several studies [4,5] have shown that older men and women transition more frequently from intermittent to continuous mobility limitation, than from no mobility limitation to intermittent mobility limitation. It is however possible to recover mobility after being disabled for 3 months (40% recovery rate) or even for 6 months (30% recovery rate). These findings suggest the road to disability in elderly is a dynamic process and offers several opportunities to restore function and recover independence [4,5,6,7].
Muscle strength is a strong predictor of severe mobility limitation, slow gait speed, increased fall risk, risk of hospitalization, and high mortality rate. For example, older adults with low muscle strength have a 2.6-fold greater risk of severe mobility limitation, 4.3-fold greater risk for slow gait speed, and 2.1-fold greater risk of mortality compared to older adults with high muscle strength [8]. The loss of muscle strength in elderly cannot be explained only by the characteristic presence of skeletal muscle atrophy. Several recent research studies show that other factors such as changes in central nervous system drive, peripheral nerve dysfunction, alterations in the neuromuscular junction structure and function, fat infiltration, and a number of complex cellular and molecular changes at the level of single muscle fibers impair muscle force generation and power production [9]. In this brief review we will summarize and discuss the cellular and molecular changes at the level of muscle fibers (Fig. 2) that contribute to the above.
DEFINING SARCOPENIA
One of the most distinctive characteristics of older people is the presence of skeletal muscle weakness and atrophy. The term sarcopenia was used for the first time by Rosenberg [10,11] to refer to the loss of lean body mass with aging. More recently, the European Working Group on Sarcopenia in Older People has expanded the definition and suggested criteria for diagnosis [12] including the presence of muscle weakness (for example handgrip strength), a lower muscle mass (determined by bioelectrical impedance or dual energy X-ray absorptiometry [DEXA]), and the presence of impaired performance (slow walking speed). The FNIH Sarcopenia Project Group [13] recently recommended normative values for muscle strength and lean body mass as follows: 1) grip strength in men <26 kg and in women <16 kg, or alternate grip strength adjusted for BMI <1.0 for men and <0.56 for women; and 2) appendicular lean body mass in men <19.75 kg and <15.02 kg in women, or appendicular lean body mass adjusted for BMI in men <0.789 and <0.512 in women.
The prevalence of sarcopenia in the older population may range from 4% to 27% depending on the gender of the participants and country. In Korea, the prevalence of sarcopenia has been reported to be 11.9% in women and 12.1% in men [14]. The loss of muscle mass and strength in older people is of greater magnitude in longitudinal compared to cross-sectional studies [15]. Further, more muscle mass and strength is lost by men compared to women particularly in muscles of the lower limbs [15,16]. In fact older women have relatively well-preserved strength in the muscles of the upper limbs. It must be noted that the loss of strength with advancing age is not a universal phenomenon and some individuals maintain muscle strength after 10 years of follow-up [17]. The explanation for this variability is not clear but it has been suggested that the level of physical activity is a contributing factor. In addition to the well-described loss of force sarcopenia is also associated with the loss of muscle power (force×velocity), particularly in older people with mobility limitations [18]. Power correlates very well with function and its loss is a good predictor of impaired mobility and falls.
SATELLITE CELLS
The function of satellite cells in normal skeletal muscle is to maintain the skeletal muscle homeostasis and enable skeletal muscle regeneration. These muscle-specific Pax7-expressing adult stem cells are normally quiescent, but when stimulated by damage or stress, they become activated and enter the cell cycle to either form new muscle fibers or self-renew and replenish the satellite cell pool, that will be used in the future [19,20,21].
At the level of the individual muscle fiber, sarcopenia may be associated with a reduced number of satellite cells; especially those associated with fibers expressing type II (fast) myosin heavy chain [22]. This is relevant because the majority of the motor unit and fibers lost with advanced adult age are type II. Moreover, the satellite cell activation in response to muscle damage is blunted in older adult men. This phenomenon is mediated by interleukin-6 which is thought to be a positive regulator of satellite cells proliferation and is transiently increased after acute exercise-induced trauma [23]. With aging, interleukin-6 becomes chronically elevated and promotes muscle catabolism most likely via suppressors of cytokine signaling proteins. These events reduce the efficacy of anabolic signaling pathways such as insulin-like growth factor 1 (IGF-1).
MUSCLE FIBER SIZE, STRENGTH, AND POWER
Normal adult muscle fiber size is reached between the ages 12 and 15 years. In normal muscle, there is less than 12% difference in the largest mean fiber diameter between all three muscle fiber types [24]. Both type I and type II (a and x) adult muscle fibers are larger in men than women. In men, type II muscle fibers are usually larger than type I fibers, whereas the opposite is true in women.
The decline in muscle mass, most prominent in the lower limbs, is accompanied by a 30% to 40% decrease in muscle fiber number between the second and eight decade [25]. Further evidence has suggested that apoptosis may play a considerable role in mediating the progression of muscle fiber loss in aging [26]. Mitochondrial-mediated apoptosis has been postulated as one of the mechanisms associated with muscle fiber loss. Muscle fiber size is also affected but to a lesser extent. The reduction in muscle fiber size is fiber type specific, with 10%-40% smaller type II fibers observed in muscle tissue collected from elderly compared with young controls [27]. In contrast, type I muscle fiber size is largely unaffected [22,28,29]. These fiber type specific changes can be explained by the age-related remodeling of motor units that result mostly in denervation of type II muscle fibers with collateral re-innervation of type I muscle fibers [30,31,32].
A reduction in whole muscle and individual fiber size is a contributor to sarcopenia but may not be the most important explanation for it. Changes in muscle fiber quality (force corrected for size) have been reported by several investigators [15,27,30,31]. In other words, loss of muscle strength and power with aging can in part be explained by reductions in intrinsic force-generating capacity of skeletal muscle fibers [32,33,34,35,36]. For example, Russ et al. [34] showed that older skeletal muscle exhibits a 34% reduction in its intrinsic force-generating capacity. The mechanism underlying this reduction includes age-related alterations in cellular and molecular processes such as changes in the satellite cell population, excitation-contraction coupling, myofilament interaction, mitochondrial function, and adipocyte infiltration [37,38] (see below).
Fiber type transformation
Muscle fiber type composition can change in response to various external stimuli in a fiber type-specific fashion. For example, type I fibers are more susceptible to inactivity and denervation-induced atrophy, while type II fibers are more affected with cancer, diabetes, chronic heart failure, and aging [39]. This difference in susceptibility can be explained by the activation and response to different signaling pathways. For example the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) protects type I fibers from atrophy while the transforming growth factor beta (TGFβ) family and the nuclear factor kappaB (NF-κB) predominantly affect type IIx fibers [39]. Aging is associated with a fast-to-slow fiber type shift, affecting mostly IIx fibers. As mentioned above, these muscle fiber changes are associated with age-dependent changes in motor unit composition [40].
Excitation-contraction coupling
Excitation-contraction coupling is a physiological process that converts the sarcolemmal action potential into muscle action and force generation. One of the key elements of this process are the dihydropyridine receptors located in the transverse tubule which are needed to activate calcium release from the sarcoplasmic reticulum through the ryanodine receptor. Once calcium is released into the myoplasm, it binds to troponin C and-through interactions with troponin I and T along with tropomyosin-results in actomyosin interaction. Calcium is then pumped back into the sarcoplasmic reticulum or competitively bound. Disruption or uncoupling at any step of this process may result in reduced muscle fiber activation, force generation, and lower whole muscle strength [41].
Aging causes a reduction in the number of dihydropyridine receptors, uncoupling between these receptors and the ryanodine receptors, and deficits in calcium release [37,38]. One mechanism to explain this sequence of events is the reduction in the expression of the sarcoplasmic reticulum junctional-face membrane (JP-45) [42] that alters the levels of specific dihydropyridine receptor subunits [38,42] interfering with the protein-protein interactions involved in excitation-contraction coupling [34].
Myofilament aging
The importance of age-related changes at the level of the myofilaments has been recently discussed [43]. The majority of studies demonstrate that older men and women have reduced single fiber maximal force even after adjustments for variability in fiber size. This is true in both type I and II fibers. Many molecular mechanisms have been proposed to explain such dysfunction including a reduction in myosin protein content; this may be particularly true in immobilized muscle [32]. The latter may be related to gene transcription with abnormalities in the myostatin gene and/or reduction in translation and protein synthesis leading to a lower myosin concentration per unit of muscle cell area. In addition, post-translational modifications of myosin via mechanisms such as oxidation and glycosylation may be present. Oxidative modification of myosin may disrupt the binding of the myosin head to the actin filament and, thus, reduce the number of actin-myosin cross-bridges in the strong-binding state [44]. This will limit force and power generation. Other than receptor changes, structural alterations of myosin causing a change in the kinetics of the cross-bridge cycle, has been suggested to contribute to age-associated muscle weakness [45]. It is interesting that longitudinal studies suggest that clusters of fibers that are not lost during aging try to compensate for these age-related differences in fiber size and quality [18,46,47] and although whole muscle performance is reduced, single muscle fiber properties may be relatively well preserved.
Other mechanical properties are also altered in older human. An increased in instantaneous stiffness (reduction in elasticity) has been reported in whole muscle as well as in single fibers [33]. This may be due to an increase in the number of cross-bridges in the weak-binding state but other factors such as changes in cross-bridge compliance and sarcomeric elements like titin may contribute. As previously noted, the role of this important protein in muscle actions has been recently reviewed [48]. In conclusion, independent of the mechanism(s) limiting normal myofilament interaction, substantial evidence supports the idea that muscle impairment in older people is, at least partially, a functional and not a quantitative problem.
Adipocyte infiltration
Aging is associated with increases in both intra- and inter-muscular adipose tissue and it has been showed that increased muscle fat content is associated with reduced muscle strength [49,50]. However, a direct relationship between increased intermuscular fat and age-related muscle weakness has not been established [51]. One of the potential mechanisms explaining how fat tissue decreases muscle force is the increased tumor necrosis factor alpha (TNF-α) production. It can be suggested that TNF-α may act directly on muscle fibers disrupting excitation-contraction coupling by altering intracellular calcium stores. This has been demonstrated to be the case in cardiac myocytes [52].
Mitochondrial function
Another example of the age-related alterations in muscle cell organelles is the loss of mitochondrial content and function [53]. Mitochondria respond to multitude of intracellular signals by modulating their function: ATP production, reactive oxygen species (ROS) production, and sensitivity to permeability transition. In aging muscle, the question is whether alterations in mitochondria represent a primary organelle defect versus a secondary (potentially adaptive) response to a changing cellular environment. Sensitization to permeability transition and release of mitochondrial-derived proapoptotic factors seems to be a constant finding in aging muscle regardless of the level of physical activity [54]. There are two possible mechanisms underlying these intrinsic mitochondrial changes: 1) mitochondrial genome damage that accumulates over the years and leads to impaired synthesis of mitochondria or synthesis of mitochondria with impaired function [55] and 2) disruption of mitochondrial turnover-mitochondrial removal and replacement-which results in accumulation of damaged mitochondria with impaired function [56]. Apart from this intrinsic alteration in mitochondrial function, extrinsic factors known as 'aging milieu' including oxidative stress and muscle fiber denervation may play a very important role in mitochondrial dysfunction [54]. It is interesting to note that the loss in mitochondrial function can be partially reversed by exercise training [57]. This is supported by the higher levels of oxidative enzyme and of molecular targets associated with mitochondrial biogenesis seen in endurance octogenarian athletes.
CONCLUSION
Clinical implications of muscle fiber aging
Sarcopenia is considered by many investigators, clinicians, and public health experts as an emerging threat because it leads to a loss of functional capacity, mobility, and independence. As a result, much research has focused on interventions to slow down or reverse sarcopenia in elderly. Abundant scientific evidence supports an important role for physical exercise in the prevention and rehabilitation of age-related functional decline and development of disability. However, a better understanding of the cellular changes associated with sarcopenia is needed before more specific interventions can be designed. In this brief review we have considered the evidence showing important intrinsic changes at the level of single muscle fibers that result in muscle weakness and atrophy in elderly.
In summary, age-related muscle changes are very complex and involve multiple features and mechanisms influenced both by intrinsic and extrinsic/environmental conditions. These muscle changes may look quite different than those associated with injuries, chronic diseases, and immobilization, so the therapeutic approach must be tailored to the individual case considering the changes at the muscle cell level. In order to prevent and treat sarcopenia effectively, future research is needed to elucidate where the targeted area at the muscle fiber level is for each individual.
CONFLICTS OF INTEREST
CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported.
REFERENCES
1. World Health Organization [Internet]. Geneva: World Health Organization; c2015.cited 2015 Feb 16. Available from: http://www.who.int/
2. Countryeconomy.com [Internet]. [place unknown]: Countryeconomy.com; c2015.cited 2015 Feb 16. Available from: http://countryeconomy.com/
3. Brady AO, Straight CR, Evans EM. Body composition, muscle capacity, and physical function in older adults: an integrated conceptual model. J Aging Phys Act 2014;22:441-452.
5. Gill TM, Kurland B. The burden and patterns of disability in activities of daily living among community-living older persons. J Gerontol A Biol Sci Med Sci 2003;58:70-75.
6. Hardy SE, Dubin JA, Holford TR, Gill TM. Transitions between states of disability and independence among older persons. Am J Epidemiol 2005;161:575-584.
12. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on sarcopenia in older people. Age Ageing 2010;39:412-423.
13. Studenski SA, Peters KW, Alley DE, Cawthon PM, McLean RR, Harris TB, et al. The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci 2014;69:547-558.
14. Ryu M, Jo J, Lee Y, Chung YS, Kim KM, Baek WC. Association of physical activity with sarcopenia and sarcopenic obesity in community-dwelling older adults: the Fourth Korea National Health and Nutrition Examination Survey. Age Ageing 2013;42:734-740.
16. Yamada M, Moriguch Y, Mitani T, Aoyama T, Arai H. Age-dependent changes in skeletal muscle mass and visceral fat area in Japanese adults from 40 to 79 years-of-age. Geriatr Gerontol Int 2014;14(Suppl 1): 8-14.
17. Hughes VA, Frontera WR, Wood M, Evans WJ, Dallal GE, Roubenoff R, et al. Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health. J Gerontol A Biol Sci Med Sci 2001;56:B209-B217.
18. Reid KF, Pasha E, Doros G, Clark DJ, Patten C, Phillips EM, et al. Longitudinal decline of lower extremity muscle power in healthy and mobility-limited older adults: influence of muscle mass, strength, composition, neuromuscular activation and single fiber contractile properties. Eur J Appl Physiol 2014;114:29-39.
21. Shefer G, Van de Mark DP, Richardson JB, Yablonka-Reuveni Z. Satellite-cell pool size does matter: defining the myogenic potency of aging skeletal muscle. Dev Biol 2006;294:50-66.
22. Verdijk LB, Koopman R, Schaart G, Meijer K, Savelberg HH, van Loon LJ. Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly. Am J Physiol Endocrinol Metab 2007;292:E151-E157.
27. Frontera WR, Suh D, Krivickas LS, Hughes VA, Goldstein R, Roubenoff R. Skeletal muscle fiber quality in older men and women. Am J Physiol Cell Physiol 2000;279:C611-C618.
28. Janssen I, Heymsfield SB, Wang ZM, Ross R. Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J Appl Physiol (1985) 2000;89:81-88.
32. D'Antona G, Pellegrino MA, Adami R, Rossi R, Carlizzi CN, Canepari M, et al. The effect of ageing and immobilization on structure and function of human skeletal muscle fibres. J Physiol 2003;552(Pt 2): 499-511.
33. Ochala J, Frontera WR, Dorer DJ, Van Hoecke J, Krivickas LS. Single skeletal muscle fiber elastic and contractile characteristics in young and older men. J Gerontol A Biol Sci Med Sci 2007;62:375-381.
35. Yu F, Hedstrom M, Cristea A, Dalen N, Larsson L. Effects of ageing and gender on contractile properties in human skeletal muscle and single fibres. Acta Physiol (Oxf) 2007;190:229-241.
36. D'Antona G, Pellegrino MA, Carlizzi CN, Bottinelli R. Deterioration of contractile properties of muscle fibres in elderly subjects is modulated by the level of physical activity. Eur J Appl Physiol 2007;100:603-611.
37. Delbono O. Regulation of excitation contraction coupling by insulin-like growth factor-1 in aging skeletal muscle. J Nutr Health Aging 2000;4:162-164.
40. Ciciliot S, Rossi AC, Dyar KA, Blaauw B, Schiaffino S. Muscle type and fiber type specificity in muscle wasting. Int J Biochem Cell Biol 2013;45:2191-2199.
42. Anderson AA, Altafaj X, Zheng Z, Wang ZM, Delbono O, Ronjat M, et al. The junctional SR protein JP-45 affects the functional expression of the voltage-dependent Ca2+ channel Cav1.1. J Cell Sci 2006;119(Pt 10): 2145-2155.
44. Moen RJ, Klein JC, Thomas DD. Electron paramagnetic resonance resolves effects of oxidative stress on muscle proteins. Exerc Sport Sci Rev 2014;42:30-36.
45. Lowe DA, Thomas DD, Thompson LV. Force generation, but not myosin ATPase activity, declines with age in rat muscle fibers. Am J Physiol Cell Physiol 2002;283:C187-C192.
48. Monroy JA, Powers KL, Gilmore LA, Uyeno TA, Lindstedt SL, Nishikawa KC. What is the role of titin in active muscle. Exerc Sport Sci Rev 2012;40:73-78.
49. Goodpaster BH, Carlson CL, Visser M, Kelley DE, Scherzinger A, Harris TB, et al. Attenuation of skeletal muscle and strength in the elderly: the Health ABC Study. J Appl Physiol (1985) 2001;90:2157-2165.
50. Goodpaster BH, Kelley DE, Thaete FL, He J, Ross R. Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. J Appl Physiol (1985) 2000;89:104-110.
51. Delmonico MJ, Harris TB, Visser M, Park SW, Conroy MB, Velasquez-Mieyer P, et al. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr 2009;90:1579-1585.
52. Reid MB, Lannergren J, Westerblad H. Respiratory and limb muscle weakness induced by tumor necrosis factor-alpha: involvement of muscle myofilaments. Am J Respir Crit Care Med 2002;166:479-484.
53. Broskey NT, Greggio C, Boss A, Boutant M, Dwyer A, Schlueter L, et al. Skeletal muscle mitochondria in the elderly: effects of physical fitness and exercise training. J Clin Endocrinol Metab 2014;99:1852-1861.
55. Hiona A, Leeuwenburgh C. The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging. Exp Gerontol 2008;43:24-33.
56. Joseph AM, Adhihetty PJ, Wawrzyniak NR, Wohlgemuth SE, Picca A, Kujoth GC, et al. Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging. PLoS One 2013;8:e69327.
57. Trappe S, Hayes E, Galpin A, Kaminsky L, Jemiolo B, Fink W, et al. New records in aerobic power among octogenarian lifelong endurance athletes. J Appl Physiol (1985) 2013;114:3-10.
Percentage of old people in South Korea (A) in comparison with other developed countries (B) from 1960 to 2050 (projected). OECD, Organization for Economic Co-operation and Development.
Fig. 2
Cellular and molecular changes at the level of muscle fibers that contribute to muscle aging.
Figure & Data
References
Citations
Citations to this article as recorded by
17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson’s Disease Progression in Male Mice Xiang Zuo, Hui-Juan Bai, Qi-Li Zhao, Shu-Hui Zhang, Xin Zhao, Xi-Zeng Feng Molecular Neurobiology.2025; 62(3): 3053. CrossRef
Which Outcomes Should We be Using in Critical Care Nutrition Trials? Naomi Watson, Saira Nazeer, Zudin Puthucheary Critical Care Clinics.2025; 41(2): 363. CrossRef
Skeletal Muscle mRNA Splicing Variants Association With Four Different Fitness and Energetic Measures in the GESTALT Study Stefano Donega, Nirad Banskota, Esha Gupta, Marta Gonzalez‐Freire, Ann Zenobia Moore, Ceereena Ubaida‐Mohien, Rachel Munk, Linda Zukley, Yulan Piao, Chris Bergeron, Jan Bergeron, Arsun Bektas, Marta Zampino, Carole Stagg, Fred Indig, Lisa M. Hartnell, Mar Journal of Cachexia, Sarcopenia and Muscle.2025;[Epub] CrossRef
The Possible Roles of β-alanine and L-carnosine in Anti-aging Amin Gasmi, Pavan Kumar Mujawdiya, Roman Lysiuk, Mariia Shanaida, Massimiliano Peana, Salva Piscopo, Nataliya Beley, Svitlana Dzyha, Kateryna Smetanina, Volodymyr Shanaida, Stephane Resimont, Geir Bjorklund Current Medicinal Chemistry.2025; 32(1): 6. CrossRef
From molecular to physical function: The aging trajectory Tom A.H. Janssen, Caroline V. Lowisz, Stuart Phillips Current Research in Physiology.2025; 8: 100138. CrossRef
Focused Electric Field Technology: A Novel Myoelectrical Stimulation Technology for Noninvasive Aging Muscle Rejuvenation Boyang Jiang, Bingbing Chen, Jia Xu, Jieshu Luo, Min Yao Journal of Cosmetic Dermatology.2025;[Epub] CrossRef
Reversing Decline in Aging Muscles: Expected Trends, Impacts and Remedies Matthew Halma, Paul Marik, Joseph Varon, Jack Tuszynski Journal of Functional Morphology and Kinesiology.2025; 10(1): 29. CrossRef
Change in D3Cr muscle mass in oldest old men and its association with changes in grip strength and walking speed Megan Hetherington-Rauth, Chuck E. McCulloch, William J. Evans, Marc Hellerstein, Mahalakshmi Shankaran, Jane A. Cauley, Kris Ensrud, Lisa Langsetmo, Eric S. Orwoll, Peggy M. Cawthon, Diego A. Bonilla PLOS ONE.2025; 20(4): e0320752. CrossRef
Age-Associated Differences in Recovery from Exercise-Induced Muscle Damage Donna Ching Wah Li, Stefan Rudloff, Henning Tim Langer, Kristina Norman, Catrin Herpich Cells.2024; 13(3): 255. CrossRef
Multicomponent and power training with elastic bands improve metabolic and inflammatory parameters, body composition and anthropometry, and physical function in older women with metabolic syndrome: A 20-week randomized, controlled trial Pedro Gargallo, Eva Tamayo, Pablo Jiménez-Martínez, Alvaro Juesas, Jose Casaña, Josep C. Benitez-Martinez, Javier Gene-Morales, Julio Fernandez-Garrido, Guillermo T. Saez, Juan C. Colado Experimental Gerontology.2024; 185: 112340. CrossRef
Age and dietary restriction modulate mitochondrial quality in quadriceps femoris muscle of male mice Ting-Rui Zhang, Chun-Hsien Chiang, Tzu-Chieh Hsu, Chih-Yun Wang, Ching-Yi Chen Biogerontology.2024; 25(3): 447. CrossRef
Funktionelle Unterschiede bei den Skelettmuskelfasern und ihr Bezug zu Gebrauch und Funktionsstörungen L. Beyer Manuelle Medizin.2024; 62(2): 116. CrossRef
Mouth opening limitation and influence of age and surgical location for static fully guided dental implant placement: an observational, cross-sectional clinical study J. Gargallo-Albiol, J. Ortega-Martínez, O. Salomó-Coll, A.P. López-Boado, D. Paternostro-Betancourt, F. Hernández-Alfaro International Journal of Oral and Maxillofacial Surgery.2024; 53(6): 526. CrossRef
Muscle fibre size and myonuclear positioning in trained and aged humans Edmund Battey, Yotam Levy, Ross D. Pollock, Jamie N. Pugh, Graeme L. Close, Michaeljohn Kalakoutis, Norman R. Lazarus, Stephen D. R. Harridge, Julien Ochala, Matthew J. Stroud Experimental Physiology.2024; 109(4): 549. CrossRef
Effects of Supplemental Vitamin D3, Omega-3 Fatty Acids on Physical Performance Measures in the VITamin D and OmegA-3 TriaL Sharon H Chou, Nancy R Cook, Gregory Kotler, Eunjung Kim, Trisha Copeland, I Min Lee, Peggy M Cawthon, Julie E Buring, JoAnn E Manson, Meryl S LeBoff The Journal of Clinical Endocrinology & Metabolism.2024; 110(1): e44. CrossRef
Effect of high‐fat diet on isometric, concentric and eccentric contractile performance of skeletal muscle isolated from female CD‐1 mice Jason Tallis, Rob S. James, Emma L. J. Eyre, Sharn P. Shelley, Cameron Hill, Derek Renshaw, Josh Hurst Experimental Physiology.2024; 109(7): 1163. CrossRef
Examining variations in body composition among patients with colorectal cancer according to site and disease stage Mayra Laryssa da Silva Nascimento, Nithaela Alves Bennemann, Iasmin Matias de Sousa, Mara Rubia de Oliveira Bezerra, Gabriela Villaça Chaves, Sara Maria Moreira Lima Verde, Silvia Fernandes Maurício, José Barreto Campello Carvalheira, Maria Carolina Santo Scientific Reports.2024;[Epub] CrossRef
Examining the mediating role of muscle quantity in adolescents: associations with adiposity, cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors Neiva Leite, Maiara C. Tadiotto, Frederico B. de Moraes Junior, Francisco J. de Menezes-Junior, Patricia R. P. Corazza, Larissa R. da Silva, Wendell A. Lopes, Oslei de Matos, Rosana B. Radominski, Manuel J. Coelho-e-Silva Scientific Reports.2024;[Epub] CrossRef
Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity Feng-Min Zhang, Hao-Fan Wu, Ke-Fan Wang, Ding-Ye Yu, Xian-Zhong Zhang, Qi Ren, Wei-Zhe Chen, Feng Lin, Zhen Yu, Cheng-Le Zhuang Cell Death & Disease.2024;[Epub] CrossRef
Alternative Treatments to Exercise for the Attenuation of Disuse-Induced Skeletal Muscle Atrophy in Rats Jinho Park, T. Brock Symons, Eun Hye Kwon, Eunhee Chung, Sukho Lee Muscles.2024; 3(3): 224. CrossRef
Knee muscle strength and steadiness for individuals with anterior cruciate ligament reconstruction and knee osteoarthritis Nicholas L. Hunt, Matthew V. Robinett, Tyler N. Brown Clinical Biomechanics.2024; 119: 106331. CrossRef
Age-associated functional healing of musculoskeletal trauma through regenerative engineering and rehabilitation Krista M. Habing, Cynthia A. Alcazar, Victoria R. Duke, Yong How Tan, Nick J. Willett, Karina H. Nakayama Biomaterials Science.2024; 12(20): 5186. CrossRef
Calf Circumference Cutoff Point for Sarcopenia Screening in Community-Dwelling Older Brazilians Tainá de Castro Oliveira, Sabrina Gabrielle Gomes Fernandes, Rafaella Silva dos Santos Aguiar Gonçalves, Weslley Barbosa Sales, Luiz Eduardo Lima de Andrade, Edgar Ramos Vieira, Álvaro Campos Cavalcanti Maciel Physical & Occupational Therapy In Geriatrics.2024; : 1. CrossRef
The role of amino acids in skeletal muscle health and sarcopenia: A narrative review Ramendu Hom Chaudhuri The Journal of Biomedical Research.2024; 38: 1. CrossRef
Exercise is medicine: how should medicine embrace exercise as a key therapeutic tool? Jae-Young Lim Journal of the Korean Medical Association.2024; 67(9): 552. CrossRef
Age-Related Homeostatic Plasticity at Rodent Neuromuscular Junctions Yizhi Li, Yomna Badawi, Stephen D. Meriney Cells.2024; 13(20): 1684. CrossRef
Effects of age on human skeletal muscle: a systematic review and meta-analysis of myosin heavy chain isoform protein expression, fiber size, and distribution Christopher Lee, Philip C. Woods, Amanda E. Paluch, Mark S. Miller American Journal of Physiology-Cell Physiology.2024; 327(6): C1400. CrossRef
Reference values for respiratory muscle strength and maximal voluntary ventilation in the Brazilian adult population: A multicentric study Palomma Russelly Saldanha Araújo, Jéssica Danielle Medeiros da Fonseca, Ana Aline Marcelino, Marlene Aparecida Moreno, Arméle de Fátima Dornelas de Andrade, Matias Otto Yañez, Rodrigo Torres-Castro, Vanessa Regiane Resqueti, Guilherme Augusto de Freitas F PLOS ONE.2024; 19(11): e0313209. CrossRef
Diet and exercise in frailty and sarcopenia. Molecular aspects Fernando Millan-Domingo, Esther Garcia-Dominguez, Juan Gambini, Gloria Olaso-Gonzalez, Jose Viña, Maria Carmen Gomez-Cabrera Molecular Aspects of Medicine.2024; 100: 101322. CrossRef
Neurogenic Aging After Spinal Cord Injury: Highlighting the Unique Characteristics of Aging After Spinal Cord Injury Brittany L. Tretter, David R. Dolbow, Vincent Ooi, Gary J. Farkas, Joshua M. Miller, Jakob N. Deitrich, Ashraf S. Gorgey Journal of Clinical Medicine.2024; 13(23): 7197. CrossRef
Factors, mechanisms and improvement methods of muscle strength loss Kaiyong Wang, Xuyu Wang, Yanqiu Wang Frontiers in Cell and Developmental Biology.2024;[Epub] CrossRef
Exploring determinant factors influencing muscle quality and sarcopenia in Bilbao’s older adult population through machine learning: A comprehensive analysis approach Naiara Virto, Danielle Marie Dequin, Xabier Río, Amaia Méndez-Zorrilla, Begoña García-Zapirain, Mehmet Baysal PLOS ONE.2024; 19(12): e0316174. CrossRef
Whey protein and vitamin D supplementation in institutionalized older adults: A randomized trial Tamy Colonetti, Antônio Jose Grande, Franciani Rodrigues da Rocha, Eduardo Ronconi Dondossola, Lisiane Tuon, Hajiv Gomes Batista Teles, Bruno Minotto Bom, Laura Colonetti, Maria Inês da Rosa Nutrition and Health.2023; 29(1): 129. CrossRef
A Constitutive Model to Characterize In Vivo Human Palmar Tissue Maedeh Shojaeizadeh, Victoria Spartacus, Carolyn J. Sparrey Journal of Biomechanical Engineering.2023;[Epub] CrossRef
Changes in Body Mass Index on the Risk of Back Pain: Estimating the Impacts of Weight Gain and Loss Takaaki Ikeda, Upul Cooray, Yuta Suzuki, Anna Kinugawa, Masayasu Murakami, Ken Osaka, Lewis A Lipsitz The Journals of Gerontology: Series A.2023; 78(6): 973. CrossRef
Sarcopenia in Immune-Mediated Rheumatic Diseases—Review Rafaela Cavalheiro do Espírito Santo, Joshua F. Baker, Leonardo Peterson dos Santos, Mariana Marchezan Menezes da Silva, Ricardo Machado Xavier JCR: Journal of Clinical Rheumatology.2023; 29(7): 354. CrossRef
Value of conventional ultrasound and shear wave elastography in the assessment of muscle mass and function in elderly people with type 2 diabetes Zi-Tong Chen, Feng-Shan Jin, Le-Hang Guo, Xiao-Long Li, Qiao Wang, Hui Zhao, Li-Ping Sun, Hui-Xiong Xu European Radiology.2023; 33(6): 4007. CrossRef
Effect of resistance training on local muscle endurance in middle-aged and older adults: A systematic review with meta-analysis and meta-regression Boliang Wang, Timothy B. Davies, Kimberley L. Way, Derek L. Tran, Glen M. Davis, Maria Fiatarone Singh, Daniel A. Hackett Archives of Gerontology and Geriatrics.2023; 109: 104954. CrossRef
Fiber-Type Shifting in Sarcopenia of Old Age: Proteomic Profiling of the Contractile Apparatus of Skeletal Muscles Paul Dowling, Stephen Gargan, Dieter Swandulla, Kay Ohlendieck International Journal of Molecular Sciences.2023; 24(3): 2415. CrossRef
Metabolic Impact of Frailty Changes Diabetes Trajectory Alan J. Sinclair, Ahmed H. Abdelhafiz Metabolites.2023; 13(2): 295. CrossRef
Skeletal muscle aging and sarcopenia: Perspectives from mechanical studies of single permeabilized muscle fibers Jae-Young Lim, Walter R. Frontera Journal of Biomechanics.2023; 152: 111559. CrossRef
Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent Deeksha Malhan, Müge Yalçin, Britt Schoenrock, Dieter Blottner, Angela Relógio npj Microgravity.2023;[Epub] CrossRef
Klotho Null Mutation Involvement in Adenosine A2B Receptor–Related Skeletal Muscle Degeneration Hung-Liang Pai, Pei-Yu Wu, De-Ming Chen, Zhi-Jia Chen, Yi-Sun Yang, Han-Hsin Chang, David Pei-Cheng Lin The American Journal of Pathology.2023; 193(7): 950. CrossRef
Influence of age on force and re-lengthening dynamics after tetanic stimulation withdrawal in the tibialis anterior muscle M. Cogliati, A. Cudicio, M. Benedini, H. V. Cabral, F. Negro, C. Reggiani, C. Orizio European Journal of Applied Physiology.2023; 123(8): 1825. CrossRef
Estimating the relative load from movement velocity in the seated chest press exercise in older adults Diogo Luís Marques, Henrique Pereira Neiva, Daniel Almeida Marinho, Ivan Miguel Pires, Célia Nunes, Mário Cardoso Marques, Francesco Lucertini PLOS ONE.2023; 18(5): e0285386. CrossRef
Slo1 deficiency impaired skeletal muscle regeneration and slow‐twitch fibre formation Chao Xia, Yonghui Wang, Tianyuan Jiang, Yan Hu, Yang Chen, Xinrun Ma, Xuemei Zhang, Yanhong Gao Journal of Cachexia, Sarcopenia and Muscle.2023; 14(4): 1737. CrossRef
Metabolic Characteristics of Frail Older People with Diabetes Mellitus—A Systematic Search for Phenotypes Ahmed H. Abdelhafiz, Grace L. Keegan, Alan J. Sinclair Metabolites.2023; 13(6): 705. CrossRef
Accurate SARC-F Score in Patients with Liver Disease Masahiro Matsui, Akira Asai, Kosuke Ushiro, Saori Onishi, Tomohiro Nishikawa, Keisuke Yokohama, Hideko Ohama, Yusuke Tsuchimoto, Soo Ki Kim, Hiroki Nishikawa Diagnostics.2023; 13(11): 1959. CrossRef
Aging disrupts gene expression timing during muscle regeneration Jesse V. Kurland, Alicia A. Cutler, Jacob T. Stanley, Nicole Dalla Betta, Ashleigh Van Deusen, Brad Pawlikowski, Monica Hall, Tiffany Antwine, Alan Russell, Mary Ann Allen, Robin Dowell, Bradley Olwin Stem Cell Reports.2023; 18(6): 1325. CrossRef
Role of the Inspiratory Muscles on Functional Performance From Critical Care to Hospital Discharge and Beyond in Patients With COVID-19 Magno F Formiga, Filip Dosbaba, Martin Hartman, Ladislav Batalik, Vojtech Senkyr, Ivana Radkovcova, Svatopluk Richter, Kristian Brat, Lawrence P Cahalin Physical Therapy.2023;[Epub] CrossRef
Hesperidin Ameliorates Sarcopenia through the Regulation of Inflammaging and the AKT/mTOR/FoxO3a Signaling Pathway in 22–26-Month-Old Mice Hyun-Ji Oh, Heegu Jin, Boo-Yong Lee Cells.2023; 12(15): 2015. CrossRef
Older Adults with Pre-sarcopenia/Sarcopenia have Increased Gastrocnemius Muscle Activity to Maintain Upright Postural Control at Stance Perturbation Iago Carvalho Vendramini, Caluê Papcke, Pedro Soares da Veiga Neto, Christiano Francisco dos Santos, Ricardo Aurino de Pinho, Eduardo Mendonça Scheeren Journal of Medical and Biological Engineering.2023; 43(4): 437. CrossRef
Histological study of seventeen organs from dugong (Dugong dugon) Patcharaporn Kaewmong, Pathompong Jongjit, Araya Boonkasemsanti, Kongkiat Kittiwattanawong, Piyamat Kongtueng, Pitchaya Matchimakul, Wasan Tangphokhanon, Prapawadee Pirintr, Jaruwan Khonmee, Songphon Buddhasiri, Promporn Piboon, Sonthaya Umsumarng, Raktha PeerJ.2023; 11: e15859. CrossRef
Metallothionein Gene Deficiency Facilitates the Differentiation of C2C12 Myoblasts into Slow-Twitch Myotubes Yoshito Kadota, Ryo Yamanokuchi, Nodoka Ohnishi, Mami Matsuoka, Takashige Kawakami, Masao Sato, Shinya Suzuki Biological and Pharmaceutical Bulletin.2023; 46(9): 1240. CrossRef
Comparing right and left hamstring flexibility and its association to nonspecific lowr back pain among women of different age groups Keren Sassonker, Racheli Magnezi, Daniel Moran Journal of Bodywork and Movement Therapies.2023; 36: 404. CrossRef
Effects of Resistance Exercise on Older Individuals with Sarcopenia: Sex Differences in Humans Ki-woong Noh, Sok Park Exercise Science.2023; 32(3): 255. CrossRef
The intersection of HIF-1α, O-GlcNAc, and skeletal muscle loss in chronic obstructive pulmonary disease Jinendiran Sekar, Amy H Attaway Glycobiology.2023; 33(11): 873. CrossRef
The Functional and Anatomical Impacts of Healthy Muscle Ageing James P. Charles, Karl T. Bates Biology.2023; 12(10): 1357. CrossRef
Early skeletal muscle loss in adolescent and young adult cancer patients treated with anthracycline chemotherapy Savannah V. Wooten, Fei Wang, Michael E. Roth, Guanshu Liu, J. Andrew Livingston, Behrang Amini, Susan C. Gilchrist, Michelle Hildebrandt, Eugenie S. Kleinerman Cancer Medicine.2023; 12(22): 20798. CrossRef
Muscle fiber phenotype: a culprit of abnormal metabolism and function in skeletal muscle of humans with obesity Nathan Serrano, Jon-Philippe K. Hyatt, Joseph A. Houmard, Marta Murgia, Christos S. Katsanos American Journal of Physiology-Endocrinology and Metabolism.2023; 325(6): E723. CrossRef
Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging Raquel Fernando, Anastasia V. Shindyapina, Mario Ost, Didac Santesmasses, Yan Hu, Alexander Tyshkovskiy, Sun Hee Yim, Jürgen Weiss, Vadim N. Gladyshev, Tilman Grune, José Pedro Castro Communications Biology.2023;[Epub] CrossRef
The role of mitochondria in the pathogenesis of sarcopenia: a concise review Chiara Greggi, Umberto Tarantino International Journal of Bone Fragility.2023; 3(2): 50. CrossRef
Rectus Abdominis Muscle Thickness is a Valid Measure of Cross-Sectional Area: Implications for Ultrasound Ciara R. Kelly, Marina Mourtzakis, Helena Furberg, Puneeta Tandon, Michael T. Paris Academic Radiology.2022; 29(3): 382. CrossRef
Performance in Strength Tests are Related to the History of Falls in the Elderly Women Ádria Samara N. Noronha, Matheus Barbalho, Victor S. Coswig Ageing International.2022; 47(4): 695. CrossRef
Long-term administration of red ginseng non-saponin fraction rescues the loss of skeletal muscle mass and strength associated with aging in mice Da-Eun Cho, Gwang-Muk Choi, Yong-Seok Lee, Joon-Pyo Hong, Mijung Yeom, Bombi Lee, Dae-Hyun Hahm Journal of Ginseng Research.2022; 46(5): 657. CrossRef
Resistance Training as Treatment for Sarcopenia: Examining Sex-Related Differences in Physiology and Response Ryan Cheng, Aidan Maloney, Jay Moran, Thomas H. Newman, Elizabeth C. Gardner Clinical Therapeutics.2022; 44(1): 33. CrossRef
Metabolic phenotypes explain the relationship between dysglycaemia and frailty in older people with type 2 diabetes A.H. Abdelhafiz, A.J. Sinclair Journal of Diabetes and its Complications.2022; 36(4): 108144. CrossRef
Single skeletal muscle fiber mechanical properties: a muscle quality biomarker of human aging Jae-Young Lim, Walter R. Frontera European Journal of Applied Physiology.2022; 122(6): 1383. CrossRef
Metabolic footprint in young, middle-aged and elderly rats with melatonin deficit Jana Tchekalarova, Petar Hrischev, Petya Ivanova, Nikolai Boyadjiev, Katerina Georgieva Physiology & Behavior.2022; 250: 113786. CrossRef
Poorer outcomes associated with sarcopenia following emergency laparotomy: a systematic review and meta‐analysis Zi Qin Ng, Ryan Cohen, Philip Misur, Dieter G. Weber ANZ Journal of Surgery.2022; 92(12): 3145. CrossRef
Hypoglycaemic therapy in frail older people with type 2 diabetes mellitus—a choice determined by metabolic phenotype Alan J. Sinclair, Daniel Pennells, Ahmed H. Abdelhafiz Aging Clinical and Experimental Research.2022; 34(9): 1949. CrossRef
Feasibility and Safety of Whole-Body Electromyostimulation in Frail Older People—A Pilot Trial Joerg Bloeckl, Sebastian Raps, Michael Weineck, Robert Kob, Thomas Bertsch, Wolfgang Kemmler, Daniel Schoene Frontiers in Physiology.2022;[Epub] CrossRef
Low-Volume Squat Jump Training Improves Functional Performance Independent of Myofibre Changes in Inactive Young Male Individuals Ashwin Wayne Isaacs, Kathryn Helen Myburgh, Filippo Macaluso Healthcare.2022; 10(7): 1217. CrossRef
The role of the aging microenvironment on the fate of PDGFRβ lineage cells in skeletal muscle repair Aiping Lu, Chieh Tseng, Ping Guo, Zhanguo Gao, Kaitlyn E. Whitney, Mikhail G. Kolonin, Johnny Huard Stem Cell Research & Therapy.2022;[Epub] CrossRef
Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle Matthew A. Romero, Petey W. Mumford, Paul A. Roberson, Shelby C. Osburn, Kaelin C. Young, John M. Sedivy, Michael D. Roberts Exercise and Sport Sciences Reviews.2022; 50(4): 185. CrossRef
Effect of the ACTN-3 gene polymorphism on functional fitness and executive function of elderly Jessica Salles Henrique, Pedro Luiz Garcia Braga, Sandro Soares de Almeida, Nathalia Santanna Petraconi Nunes, Izabelle Dias Benfato, Ricardo Mario Arida, Camila Aparecida Machado de Oliveira, Sérgio Gomes da Silva Frontiers in Aging Neuroscience.2022;[Epub] CrossRef
Suppressive Effects of Turmeric Extract on Muscle Atrophy in Dexamethasone-Treated Mice and Myotubes Kyohei Furukawa, Marika Kousaka, Huijuan Jia, Hisanori Kato Nutrients.2022; 14(19): 3979. CrossRef
Untargeted muscle tissue metabolites profiling in young, adult, and old rats supplemented with tocotrienol-rich fraction Siti Liyana Saud Gany, Jen Kit Tan, Kok Yong Chin, Nur Haleeda Hakimi, Nazirah Ab Rani, Nurhazirah Ihsan, Suzana Makpol Frontiers in Molecular Biosciences.2022;[Epub] CrossRef
Age-Related Changes in Skeletal Muscle Oxygen Utilization Sabrina S. Salvatore, Kyle N. Zelenski, Ryan K. Perkins Journal of Functional Morphology and Kinesiology.2022; 7(4): 87. CrossRef
Organotypic cultures as aging associated disease models Martina M. Sanchez, Isabella A. Bagdasarian, William Darch, Joshua T. Morgan Aging.2022; 14(22): 9338. CrossRef
Associations between Body Mass Index, Waist Circumference, and Myocardial Infarction in Older Adults Aged over 75 Years: A Population-Based Cohort Study So Yoon Han, Nan Hee Kim, Do Hoon Kim, Yang Hyun Kim, Yong Kyu Park, Seon Mee Kim Medicina.2022; 58(12): 1768. CrossRef
Real-Life Outcomes of a Multicomponent Exercise Intervention in Community-Dwelling Frail Older Adults and Its Association with Nutritional-Related Factors Fernando Millan-Domingo, Francisco Jose Tarazona-Santabalbina, Aitor Carretero, Gloria Olaso-Gonzalez, Jose Viña, Maria Carmen Gomez-Cabrera Nutrients.2022; 14(23): 5147. CrossRef
Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence Kevin Perez, Serban Ciotlos, Julia McGirr, Chandani Limbad, Ryosuke Doi, Joshua P. Nederveen, Mats I. Nilsson, Daniel A. Winer, William Evans, Mark Tarnopolsky, Judith Campisi, Simon Melov Aging.2022;[Epub] CrossRef
Bioengineered Skeletal Muscle as a Model of Muscle Aging and Regeneration Nika Rajabian, Aref Shahini, Mohammadnabi Asmani, Kalyan Vydiam, Debanik Choudhury, Thy Nguyen, Izuagie Ikhapoh, Ruogang Zhao, Pedro Lei, Stelios T. Andreadis Tissue Engineering Part A.2021; 27(1-2): 74. CrossRef
Relationship Between Low Handgrip Strength and Chronic Kidney Disease: KNHANES 2014-2017 Yae Lim Lee, Heejin Jin, Jae-Young Lim, Sang Yoon Lee Journal of Renal Nutrition.2021; 31(1): 57. CrossRef
Responsiveness to muscle mass gain following 12 and 24 weeks of resistance training in older women João Pedro Nunes, Fábio L. C. Pina, Alex S. Ribeiro, Paolo M. Cunha, Witalo Kassiano, Bruna D. V. Costa, Gabriel Kunevaliki, Matheus A. Nascimento, Nelson H. Carneiro, Danielle Venturini, Décio S. Barbosa, Analiza M. Silva, Jerry L. Mayhew, Luís B. Sardin Aging Clinical and Experimental Research.2021; 33(4): 1071. CrossRef
Association Between Muscle Quality Measured by Abdominal Computed Tomography and Subclinical Coronary Atherosclerosis Min Jung Lee, Hong-Kyu Kim, Eun Hee Kim, Sung Jin Bae, Kyung Won Kim, Min-Ju Kim, Jaewon Choe Arteriosclerosis, Thrombosis, and Vascular Biology.2021;[Epub] CrossRef
Associations of muscle lipid content with physical function and resistance training outcomes in older adults: altered responses with metformin Douglas E. Long, Bailey D. Peck, Steven C. Tuggle, Alejandro G. Villasante Tezanos, Samuel T. Windham, Marcas M. Bamman, Philip A. Kern, Charlotte A. Peterson, Rosicka G. Walton GeroScience.2021; 43(2): 629. CrossRef
Dose-Response Relationship between Endurance Training Prescription Variables and Increases in Aerobic Performance of Healthy and Unhealthy Middle and Very Old Individuals Aged 70 Years and Older: A Systematic Review and Meta-Analysis of Randomized Control Sarah Cheour, Chouaib Cheour, Nicola Luigi Bragazzi, Liye Zou, Armin H. Paravlic, Maamer Slimani, Foued Cheour Life.2021; 11(2): 121. CrossRef
Identification of new biomarkers for sarcopenia and characterization of cathepsin D biomarker Corine L'hôte, Benoît Cordier, Alain Labasse, Christelle Boileau, Bérénice Costes, Yves Henrotin JCSM Rapid Communications.2021; 4(2): 122. CrossRef
Skeletal muscle mitochondrial DNA copy number and mitochondrial DNA deletion mutation frequency as predictors of physical performance in older men and women Allen Herbst, Steven J. Prior, Cathy C. Lee, Judd M. Aiken, Debbie McKenzie, Austin Hoang, Nianjun Liu, Xiwei Chen, Pengcheng Xun, David B. Allison, Jonathan Wanagat GeroScience.2021; 43(3): 1253. CrossRef
Redox Homeostasis and Metabolic Profile in Young Female Basketball Players during in-Season Training Rosamaria Militello, Simone Luti, Matteo Parri, Riccardo Marzocchini, Riccardo Soldaini, Alessandra Modesti, Pietro Amedeo Modesti Healthcare.2021; 9(4): 368. CrossRef
Vitamin D3supplementation does not enhance the effects of resistance training in older adults Knut Sindre Mølmen, Daniel Hammarström, Karianne Pedersen, Anne Cecilie Lian Lie, Ragnvald B. Steile, Håvard Nygaard, Yusuf Khan, Håvard Hamarsland, Lise Koll, Marita Hanestadhaugen, Atle Lie Eriksen, Eirik Grindaker, Jon Elling Whist, Daniel Buck, Rafi A Journal of Cachexia, Sarcopenia and Muscle.2021; 12(3): 599. CrossRef
Analysis of the aging-induced changes in the motor ability structure using large population fitness test results Prabhat Pathak, Siddhartha Bikram Panday, Bong-Keun Jung, Jooeun Ahn Aging.2021; 13(1): 150. CrossRef
The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function Zachary Clemens, Sruthi Sivakumar, Abish Pius, Amrita Sahu, Sunita Shinde, Hikaru Mamiya, Nathaniel Luketich, Jian Cui, Purushottam Dixit, Joerg D Hoeck, Sebastian Kreuz, Michael Franti, Aaron Barchowsky, Fabrisia Ambrosio eLife.2021;[Epub] CrossRef
Screening for Sarcopenia (Physical Frailty) in the COVID-19 Era Amira Mohammed Ali, Hiroshi Kunugi, Gerardo Garcia-Rivas International Journal of Endocrinology.2021; 2021: 1. CrossRef
Impact of frailty metabolic phenotypes on the management of older people with type 2 diabetes mellitus Ahmed H Abdelhafiz, Demelza Emmerton, Alan J Sinclair Geriatrics & Gerontology International.2021; 21(8): 614. CrossRef
Handgrip Strength: An Irreplaceable Indicator of Muscle Function Sang Yoon Lee Annals of Rehabilitation Medicine.2021; 45(3): 167. CrossRef
Physical Frailty/Sarcopenia as a Key Predisposing Factor to Coronavirus Disease 2019 (COVID-19) and Its Complications in Older Adults Amira Mohammed Ali, Hiroshi Kunugi BioMed.2021; 1(1): 11. CrossRef
Advanced Glycation End Products Are Retained in Decellularized Muscle Matrix Derived from Aged Skeletal Muscle Lucas C. Olson, Tri M. Nguyen, Rebecca L. Heise, Barbara D. Boyan, Zvi Schwartz, Michael J. McClure International Journal of Molecular Sciences.2021; 22(16): 8832. CrossRef
Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle Yuhei Mizunoe, Masaki Kobayashi, Hiroki Saito, Akifumi Goto, Ryota Migitaka, Kumi Miura, Naoyuki Okita, Yuka Sudo, Ryoma Tagawa, Miki Yoshida, Ai Umemori, Yoshimi Nakagawa, Hitoshi Shimano, Yoshikazu Higami Experimental Gerontology.2021; 154: 111519. CrossRef
ACTN3 Genotypes and Their Relationship with Muscle Mass and Function of Kosovan Adults Arben Boshnjaku, Ermira Krasniqi, Harald Tschan, Barbara Wessner International Journal of Environmental Research and Public Health.2021; 18(17): 9135. CrossRef
Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer’s Disease: Studies in the 3xTg-AD Mice Lidia Castillo-Mariqueo, M. José Pérez-García, Lydia Giménez-Llort Biomedicines.2021; 9(10): 1365. CrossRef
Effect of the COVID-19 pandemic on the physical and psychoaffective health of older adults in a physical exercise program Mikel Markotegi, Jon Irazusta, Begoña Sanz, Ana Rodriguez-Larrad Experimental Gerontology.2021; 155: 111580. CrossRef
Association of Appendicular Skeletal Muscle Mass and Central Obesity Parameters with Lipid Profiles in Older Women Lazuardhi Dwipa, Syarief Hidayat, Senov Eka Permadi, Evan Susandi, Alif Bagus Rakhimullah, Yuni Susanti Pratiwi Open Access Macedonian Journal of Medical Sciences.2021; 9(B): 921. CrossRef
The ERG1A K+ Channel Is More Abundant in Rectus abdominis Muscle from Cancer Patients Than that from Healthy Humans Sandra Zampieri, Marco Sandri, Joseph L. Cheatwood, Rajesh P. Balaraman, Luke B. Anderson, Brittan A. Cobb, Chase D. Latour, Gregory H. Hockerman, Helmut Kern, Roberta Sartori, Barbara Ravara, Stefano Merigliano, Gianfranco Da Dalt, Judith K. Davie, Punit Diagnostics.2021; 11(10): 1879. CrossRef
Advanced Glycation End-Products in Skeletal Muscle Aging Lucas C. Olson, James T. Redden, Zvi Schwartz, David J. Cohen, Michael J. McClure Bioengineering.2021; 8(11): 168. CrossRef
Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans Daisuke Hasegawa, Amane Hori, Yukiko Okamura, Reizo Baba, Kenichi Suijo, Masaki Mizuno, Jun Sugawara, Koji Kitatsuji, Hisayoshi Ogata, Kaoru Toda, Norio Hotta Physiological Reports.2021;[Epub] CrossRef
Do skeletal muscle composition and gene expression as well as acute exercise-induced serum adaptations in older adults depend on fitness status? Daniel A. Bizjak, Martina Zügel, Uwe Schumann, Mark A. Tully, Dhayana Dallmeier, Michael Denkinger, Jürgen M. Steinacker BMC Geriatrics.2021;[Epub] CrossRef
Assessing the Effects of Aging on Muscle Stiffness Using Shear Wave Elastography and Myotonometer Yerim Do, Prarthana Sanya Lall, Haneul Lee Healthcare.2021; 9(12): 1733. CrossRef
Quality Matters as Much as Quantity of Skeletal Muscle: Clinical Implications of Myosteatosis in Cardiometabolic Health Hong-Kyu Kim, Chul-Hee Kim Endocrinology and Metabolism.2021; 36(6): 1161. CrossRef
Neuromuscular junction transmission failure is a late phenotype in aging mice Deepti Chugh, Chitra C. Iyer, Xueyong Wang, Prameela Bobbili, Mark M. Rich, W. David Arnold Neurobiology of Aging.2020; 86: 182. CrossRef
Microstructural analysis of skeletal muscle force generation during aging Yantao Zhang, Jiun‐Shyan Chen, Qizhi He, Xiaolong He, Ramya R. Basava, John Hodgson, Usha Sinha, Shantanu Sinha International Journal for Numerical Methods in Biomedical Engineering.2020;[Epub] CrossRef
Relationship between serum vitamin D level and sarcopenia in chronic liver disease Tomomi Okubo, Masanori Atsukawa, Akihito Tsubota, Yuji Yoshida, Taeang Arai, Ai‐Nakagawa Iwashita, Norio Itokawa, Chisa Kondo, Katsuhiko Iwakiri Hepatology Research.2020; 50(5): 588. CrossRef
Mitochondrial function in skeletal myofibers is controlled by a TRF2‐SIRT3 axis over lifetime Jérôme D. Robin, Maria‐Sol Jacome Burbano, Han Peng, Olivier Croce, Jean Luc Thomas, Camille Laberthonniere, Valerie Renault, Liudmyla Lototska, Mélanie Pousse, Florent Tessier, Serge Bauwens, Waiian Leong, Sabrina Sacconi, Laurent Schaeffer, Frédérique M Aging Cell.2020;[Epub] CrossRef
Impact of Melatonin on Skeletal Muscle and Exercise Alessandra Stacchiotti, Gaia Favero, Luigi Fabrizio Rodella Cells.2020; 9(2): 288. CrossRef
Prdx6 Plays a Main Role in the Crosstalk between Aging and Metabolic Sarcopenia Francesca Pacifici, David Della-Morte, Francesca Piermarini, Roberto Arriga, Maria Giovanna Scioli, Barbara Capuani, Donatella Pastore, Andrea Coppola, Silvia Rea, Giulia Donadel, Aikaterini Andreadi, Pasquale Abete, Giuseppe Sconocchia, Alfonso Bellia, A Antioxidants.2020; 9(4): 329. CrossRef
Long-Term Recreational Football Training and Health in Aging Esther Imperlini, Annamaria Mancini, Stefania Orrù, Daniela Vitucci, Valeria Di Onofrio, Francesca Gallè, Giuliana Valerio, Giuliana Salvatore, Giorgio Liguori, Pasqualina Buono, Andreina Alfieri International Journal of Environmental Research and Public Health.2020; 17(6): 2087. CrossRef
Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial Diana Carolina Müller, Mikel Izquierdo, Francesco Pinto Boeno, Per Aagaard, Juliana Lopes Teodoro, Rafael Grazioli, Regis Radaelli, Henrique Bayer, Rodrigo Neske, Ronei Silveira Pinto, Eduardo Lusa Cadore European Journal of Applied Physiology.2020; 120(5): 1165. CrossRef
Evaluation of effects of aging on skeletal muscle elasticity using shear wave elastography Halit Nahit Şendur, Emetullah Cindil, Mahi Nur Cerit, Pınar Kılıç, Işıl İmge Gültekin, Suna Özhan Oktar European Journal of Radiology.2020; 128: 109038. CrossRef
Lean, fast and strong: Determinants of functional performance in the elderly Lucas B.R. Orssatto, Ewertton S. Bezerra, Brad J. Schoenfeld, Fernando Diefenthaeler Clinical Biomechanics.2020; 78: 105073. CrossRef
Overexpression of HSP70 attenuates sarcopenia by suppressing the expression of miR‐133b Tábata L. Nascimento, Ruben Mestril, Elen H. Miyabara JCSM Rapid Communications.2020; 3(2): 70. CrossRef
Postmenopausal osteoporosis is a musculoskeletal disease with a common genetic trait which responds to strength training: a translational intervention study Ole Kristoffer Olstad, Vigdis Teig Gautvik, Marissa LeBlanc, Karl Johnny Kvernevik, Tor Paaske Utheim, Anne Runningen, Håvard Wiig, Camilla Kirkegaard, Truls Raastad, Sjur Reppe, Kaare Morten Gautvik Therapeutic Advances in Musculoskeletal Disease.2020;[Epub] CrossRef
Predominant Neck Extensor Muscle Weakness: A Rare Manifestation of Idiopathic Polymyositis Hassan Kesserwani Cureus.2020;[Epub] CrossRef
Structural and Functional Changes in the Coupling of Fascial Tissue, Skeletal Muscle, and Nerves During Aging Alberto Zullo, Johannes Fleckenstein, Robert Schleip, Kerstin Hoppe, Scott Wearing, Werner Klingler Frontiers in Physiology.2020;[Epub] CrossRef
Multinuclear MRS at 7T Uncovers Exercise Driven Differences in Skeletal Muscle Energy Metabolism Between Young and Seniors Patrik Krumpolec, Radka Klepochová, Ivica Just, Marjeta Tušek Jelenc, Ivan Frollo, Jozef Ukropec, Barbara Ukropcová, Siegfried Trattnig, Martin Krššák, Ladislav Valkovič Frontiers in Physiology.2020;[Epub] CrossRef
Effects of Neuromuscular Electrical Stimulation Synchronized with Chewing Exercises on Bite Force and Masseter Muscle Thickness in Community-Dwelling Older Adults in South Korea: A Randomized Controlled Trial Ji-Su Park, Young-Jin Jung, Min-Ji Kim International Journal of Environmental Research and Public Health.2020; 17(13): 4902. CrossRef
Effect of long-term moderate-exercise combined with metformin-treatment on antioxidant enzymes activity and expression in the gastrocnemius of old female Wistar rats Ulalume Hernández-Arciga, David Hernández-Álvarez, Stefanie Paola López-Cervantes, Norma Edith López-Díazguerrero, Adriana Alarcón-Aguilar, Armando Luna-López, Mina Königsberg Biogerontology.2020; 21(6): 787. CrossRef
Zingiber officinale Roscoe Prevents DNA Damage and Improves Muscle Performance and Bone Integrity in Old Sprague Dawley Rats Suzana Makpol, Nur Fathiah Abdul Sani, Nur Haleeda Hakimi, Nazirah Ab Rani, Siti Nor Asyikin Zakaria, Ahmad Fais Abd Rasid, Geetha Gunasekaran, Nur Fatin Nabilah Mohd Sahardi, Jen Kit Tan, Norzana Abd Ghafar, Mariam Firdhaus Mad Nordin, Arham Shabbir Evidence-Based Complementary and Alternative Medicine.2020;[Epub] CrossRef
Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition Randall F. D’Souza, Jonathan S. T. Woodhead, Christopher P. Hedges, Nina Zeng, Junxiang Wan, Hiroshi Kumagai, Changhan Lee, Pinchas Cohen, David Cameron-Smith, Cameron J. Mitchell, Troy L. Merry Aging.2020; 12(6): 5244. CrossRef
The Genetic Effect on Muscular Changes in an Older Population: A Follow-Up Study after One-Year Cessation of Structured Training Lingxiao He, Evelien Van Roie, An Bogaerts, Sabine Verschueren, Christophe Delecluse, Christopher I. Morse, Martine Thomis Genes.2020; 11(9): 968. CrossRef
Docosahexaenoic Acid, a Potential Treatment for Sarcopenia, Modulates the Ubiquitin–Proteasome and the Autophagy–Lysosome Systems Jung Hoon Lee, Jun Hyoung Jeon, Min Jae Lee Nutrients.2020; 12(9): 2597. CrossRef
Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen Amira Mohammed Ali, Hiroshi Kunugi Foods.2020; 9(10): 1362. CrossRef
Preserved Capacity for Adaptations in Strength and Muscle Regulatory Factors in Elderly in Response to Resistance Exercise Training and Deconditioning Andreas Mæchel Fritzen, Frank D. Thøgersen, Khaled Abdul Nasser Qadri, Thomas Krag, Marie-Louise Sveen, John Vissing, Tina D. Jeppesen Journal of Clinical Medicine.2020; 9(7): 2188. CrossRef
Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A Review Amira Mohammed Ali, Hiroshi Kunugi Antioxidants.2020; 9(10): 937. CrossRef
Impacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition Hui-Ying Luk, Casey Appell, Ming-Chien Chyu, Chung-Hwan Chen, Chien-Yuan Wang, Rong-Sen Yang, Chwan-Li Shen Antioxidants.2020; 9(11): 1050. CrossRef
Morphometric and Molecular Muscle Remodeling after Passive Stretching in Elderly Female Rats Hilana Rickli Fiuza Martins, Talita G. Gnoato Zotz, Sabrina Peviani Messa, Luiz Guilherme A. Capriglione, Rafael Zotz, Lucia Noronha, Marina Louise Viola De Azevedo, Anna Raquel Silveira Gomes Clinics.2020; 75: e1769. CrossRef
AChRs Degeneration at NMJ in Aging-Associated Sarcopenia–A Systematic Review Zhengyuan Bao, Can Cui, Simon Kwoon-Ho Chow, Ling Qin, Ronald Man Yeung Wong, Wing-Hoi Cheung Frontiers in Aging Neuroscience.2020;[Epub] CrossRef
Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) R47H Variant Causes Distinct Age- and Sex-Dependent Musculoskeletal Alterations in Mice Alyson L. Essex, Joshua R. Huot, Padmini Deosthale, Alison Wagner, Jorge Figueras, Azaria Davis, John Damrath, Fabrizio Pin, Joseph Wallace, Andrea Bonetto, Lilian I. Plotkin Journal of Bone and Mineral Research.2020; 37(7): 1366. CrossRef
Resistance training induced changes in strength and specific force at the fiber and whole muscle level: a meta-analysis Scott J. Dankel, Minsoo Kang, Takashi Abe, Jeremy P. Loenneke European Journal of Applied Physiology.2019; 119(1): 265. CrossRef
The bystander effect contributes to the accumulation of senescent cells in vivo Paulo F. L. da Silva, Mikolaj Ogrodnik, Olena Kucheryavenko, Julien Glibert, Satomi Miwa, Kerry Cameron, Abbas Ishaq, Gabriele Saretzki, Sushma Nagaraja‐Grellscheid, Glyn Nelson, Thomas von Zglinicki Aging Cell.2019;[Epub] CrossRef
The association of back muscle strength and sarcopenia-related parameters in the patients with spinal disorders Hiromitsu Toyoda, Masatoshi Hoshino, Shoichiro Ohyama, Hidetomi Terai, Akinobu Suzuki, Kentaro Yamada, Shinji Takahashi, Kazunori Hayashi, Koji Tamai, Yusuke Hori, Hiroaki Nakamura European Spine Journal.2019; 28(2): 241. CrossRef
Pathophysiology of Muscle in Pulmonary and Cardiovascular Conditions Karina Tamy Kasawara, Maria Miñana Castellanos, Masatoshi Hanada, W Darlene Reid Cardiopulmonary Physical Therapy Journal.2019; 30(1): 5. CrossRef
Why Fast Velocity Resistance Training Should Be Prioritized for Elderly People Lucas Bet da Rosa Orssatto, Eduardo Lusa Cadore, Lars Louis Andersen, Fernando Diefenthaeler Strength & Conditioning Journal.2019; 41(1): 105. CrossRef
Sarcopenia and Its Implications for Metabolic Health Gary R. Hunter, Harshvardhan Singh, Stephen J. Carter, David R. Bryan, Gordon Fisher Journal of Obesity.2019; 2019: 1. CrossRef
Improved efficacy of a next-generation ERT in murine Pompe disease Su Xu, Yi Lun, Michelle Frascella, Anadina Garcia, Rebecca Soska, Anju Nair, Abdul S. Ponery, Adriane Schilling, Jessie Feng, Steven Tuske, Maria Cecilia Della Valle, José A. Martina, Evelyn Ralston, Russell Gotschall, Kenneth J. Valenzano, Rosa Puertolla JCI Insight.2019;[Epub] CrossRef
Low survival rate and muscle fiber-dependent aging effects in the McArdle disease mouse model Alberto Real-Martinez, Astrid Brull, Jordi Huerta, Guillermo Tarrasó, Alejandro Lucia, Miguel Angel Martin, Joaquin Arenas, Antoni L. Andreu, Gisela Nogales-Gadea, John Vissing, Thomas O. Krag, Noemi de Luna, Tomàs Pinós Scientific Reports.2019;[Epub] CrossRef
Osteosarcopenic Obesity: Current Knowledge, Revised Identification Criteria and Treatment Principles Owen J. Kelly, Jennifer C. Gilman, Dario Boschiero, Jasminka Z. Ilich Nutrients.2019; 11(4): 747. CrossRef
Association between echo intensity of the tongue and its thickness and function in elderly subjects Ariya Chantaramanee, Haruka Tohara, Kazuharu Nakagawa, Koji Hara, Ayako Nakane, Kohei Yamaguchi, Kanako Yoshimi, Furuya Junichi, Shunsuke Minakuchi Journal of Oral Rehabilitation.2019; 46(7): 634. CrossRef
Muscle‐bone crosstalk and potential therapies for sarco‐osteoporosis GuoBin Li, Lan Zhang, DongEn Wang, Luban AIQudsy, Jean X. Jiang, HuiYun Xu, Peng Shang Journal of Cellular Biochemistry.2019; 120(9): 14262. CrossRef
Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle Stéphanie Paradis, Anne-Laure Charles, Isabelle Georg, Fabienne Goupilleau, Alain Meyer, Michel Kindo, Gilles Laverny, Daniel Metzger, Bernard Geny Antioxidants.2019; 8(6): 168. CrossRef
Mitochondrial Dysfunction in Skeletal Muscle Pathologies Johanna Abrigo, Felipe Simon, Daniel Cabrera, Cristian Vilos, Claudio Cabello-Verrugio Current Protein & Peptide Science.2019; 20(6): 536. CrossRef
Skeletal muscle LINE-1 retrotransposon activity is upregulated in older versus younger rats Petey W. Mumford, Matthew A. Romero, Shelby C. Osburn, Paul A. Roberson, Christopher G. Vann, Christopher B. Mobley, Michael D. Brown, Andreas N. Kavazis, Kaelin C. Young, Michael D. Roberts American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2019; 317(3): R397. CrossRef
Functional Measures of Sarcopenia: Prevalence, and Associations with Functional Disability in 10,892 Adults Aged 65 Years and Over from Six Lower- and Middle-Income Countries Sharon L. Brennan-Olsen, Steven J. Bowe, Paul Kowal, Nirmala Naidoo, Nekehia T. Quashie, Geeta Eick, Sutapa Agrawal, Catherine D’Este Calcified Tissue International.2019; 105(6): 609. CrossRef
Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults Tatiana Moro, Camille R. Brightwell, Danielle E. Phalen, Colleen F. McKenna, Samantha J. Lane, Craig Porter, Elena Volpi, Blake B. Rasmussen, Christopher S. Fry Experimental Gerontology.2019; 127: 110723. CrossRef
Cistanche tubulosa (Schenk) Wight Extract Enhances Hindlimb Performance and Attenuates Myosin Heavy Chain IId/IIx Expression in Cast-Immobilized Mice Yoshiyuki Kimbara, Yutaka Shimada, Tomoharu Kuboyama, Chihiro Tohda Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1. CrossRef
Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy Spencer G. Miller, Paul S. Hafen, Jeffrey J. Brault International Journal of Molecular Sciences.2019; 21(1): 88. CrossRef
Handgrip Strength in the Korean Population: Normative Data and Cutoff Values Yae Lim Lee, Ban Hyung Lee, Sang Yoon Lee Annals of Geriatric Medicine and Research.2019; 23(4): 183. CrossRef
Aging and the Pelvic Floor Karla Wente, Christina Dolan Current Geriatrics Reports.2018; 7(1): 49. CrossRef
Leg press exercise can reduce functional hamstring:quadriceps ratio in the elderly Lucas Bet da Rosa Orssatto, Bruno Monteiro de Moura, Raphael Luiz Sakugawa, Regis Radaelli, Fernando Diefenthaeler Journal of Bodywork and Movement Therapies.2018; 22(3): 592. CrossRef
Increased skeletal muscle mitochondrial free radical production in peripheral arterial disease despite preserved mitochondrial respiratory capacity Corey R. Hart, Gwenael Layec, Joel D. Trinity, Oh Sung Kwon, Jia Zhao, Van R. Reese, Jayson R. Gifford, Russell S. Richardson Experimental Physiology.2018; 103(6): 838. CrossRef
An aPPARent Functional Consequence in Skeletal Muscle Physiology via Peroxisome Proliferator-Activated Receptors Wendy Wen Ting Phua, Melissa Xin Yu Wong, Zehuan Liao, Nguan Soon Tan International Journal of Molecular Sciences.2018; 19(5): 1425. CrossRef
A ‘musculoskeletal look’ to sarcopenia: Where do/should the physical and rehabilitation medicine physicians (physiatrists) stand? Levent Özçakar, Ayşe Merve Ata, Michael Quittan, Xanthi Michail International Journal of Rehabilitation Research.2018; 41(2): 95. CrossRef
Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration Bill Tachtsis, Donny Camera, Orly Lacham-Kaplan Nutrients.2018; 10(3): 309. CrossRef
Potential roles of vitamin E in age-related changes in skeletal muscle health Eunhee Chung, Huanbiao Mo, Shu Wang, Yujiao Zu, Manal Elfakhani, Steven R. Rios, Ming-Chien Chyu, Rong-Sen Yang, Chwan-Li Shen Nutrition Research.2018; 49: 23. CrossRef
Calf circumference: clinical validation for evaluation of muscle mass in the elderly Valéria Pagotto, Kássylla Ferreira dos Santos, Suelen Gomes Malaquias, Maria Márcia Bachion, Erika Aparecida Silveira Revista Brasileira de Enfermagem.2018; 71(2): 322. CrossRef
Der Effekt von Wachstumshormon auf die menschlichen Alterungsprozesse. Teil 1 Michael Klentze Journal für Gynäkologische Endokrinologie/Österreich.2018; 28(3): 84. CrossRef
Neuromuscular fatigue is weakly associated with perception of fatigue and function in patients with rheumatoid arthritis Rafaela Cavalheiro do Espírito Santo, Marcelo Gava Pompermayer, Rodrigo Rico Bini, Vanessa Olszewski, Elton Gonçalves Teixeira, Rafael Chakr, Ricardo Machado Xavier, Claiton Viegas Brenol Rheumatology International.2018; 38(3): 415. CrossRef
AAV1.NT-3 gene therapy increases muscle fiber diameter through activation of mTOR pathway and metabolic remodeling in a CMT mouse model Mehmet E. Yalvac, Jakkrit Amornvit, Lei Chen, Kimberly M. Shontz, Sarah Lewis, Zarife Sahenk Gene Therapy.2018; 25(2): 129. CrossRef
Neural and musculotendinous mechanisms underpinning age-related force reductions Lucas Bet da Rosa Orssatto, Matheus Joner Wiest, Fernando Diefenthaeler Mechanisms of Ageing and Development.2018; 175: 17. CrossRef
Fast and slow-twitching muscles are differentially affected by reduced cholinergic transmission in mice deficient for VAChT: A mouse model for congenital myasthenia Matheus P.S. Magalhães-Gomes, Daisy Motta-Santos, Luana P.L. Schetino, Jéssica N. Andrade, Cristiane P. Bastos, Diogo A.S. Guimarães, Sydney K. Vaughan, Patrícia M. Martinelli, Silvia Guatimosim, Grace S. Pereira, Candido C. Coimbra, Vânia F. Prado, Marco Neurochemistry International.2018; 120: 1. CrossRef
Current Status of Sarcopenia in Korea: A Focus on Korean Geripausal Women Hyoung Moo Park Annals of Geriatric Medicine and Research.2018; 22(2): 52. CrossRef
Are Canadian protein and physical activity guidelines optimal for sarcopenia prevention in older adults? Camila L.P. Oliveira, Isabelle J. Dionne, Carla M. Prado Applied Physiology, Nutrition, and Metabolism.2018; 43(12): 1215. CrossRef
Der Effekt von Wachstumshormon auf die menschlichen Alterungsprozesse. Teil 1 Michael Klentze Journal für Gynäkologische Endokrinologie/Schweiz.2018; 21(3): 76. CrossRef
Validation of a clinically-relevant rodent model of statin-associated muscle symptoms for use in pharmacological studies Jordon Candice Irwin, Andrew Stuart Fenning, Kimberly Rene Ryan, Rebecca Kate Vella Toxicology and Applied Pharmacology.2018; 360: 78. CrossRef
Effects of age and sex on shoulder biomechanics and relative effort during functional tasks Alessio Murgia, Tibor Hortobágyi, Annet Wijnen, Larissa Bruin, Ron Diercks, Rienk Dekker Journal of Biomechanics.2018; 81: 132. CrossRef
Effects of Jumping Exercise on Muscular Power in Older Adults: A Meta-Analysis Jason Moran, Rodrigo Ramirez-Campillo, Urs Granacher Sports Medicine.2018; 48(12): 2843. CrossRef
Correlation between skeletal muscle mass index and parameters of respiratory function and muscle strength in young healthy adults according to gender Yohei Sawaya, Masahiro Ishizaka, Akira Kubo, Kaori Sadakiyo, Akihiro Yakabi, Tamae Sato, Takahiro Shiba, Ko Onoda, Hitoshi Maruyama Journal of Physical Therapy Science.2018; 30(12): 1424. CrossRef
The Role of Ultrasound as a Diagnostic Tool for Sarcopenia Howard J. Stringer, D. Wilson The Journal of Frailty & Aging.2018; 7(4): 258. CrossRef
The Human Skeletal Muscle Proteome Project: a reappraisal of the current literature Marta Gonzalez‐Freire, Richard D. Semba, Ceereena Ubaida‐Mohien, Elisa Fabbri, Paul Scalzo, Kurt Højlund, Craig Dufresne, Alexey Lyashkov, Luigi Ferrucci Journal of Cachexia, Sarcopenia and Muscle.2017; 8(1): 5. CrossRef
Change in muscle strength and muscle mass in older hospitalized patients: A systematic review and meta-analysis Jeanine M. Van Ancum, Kira Scheerman, Nini H. Jonkman, Hanne E. Smeenk, Roeliene C. Kruizinga, Carel G.M. Meskers, Andrea B. Maier Experimental Gerontology.2017; 92: 34. CrossRef
Aging in Rats Differentially Affects Markers of Transcriptional and Translational Capacity in Soleus and Plantaris Muscle Christopher B. Mobley, Petey W. Mumford, Wesley C. Kephart, Cody T. Haun, Angelia M. Holland, Darren T. Beck, Jeffrey S. Martin, Kaelin C. Young, Richard G. Anderson, Romil K. Patel, Gillis L. Langston, Ryan P. Lowery, Jacob M. Wilson, Michael D. Roberts Frontiers in Physiology.2017;[Epub] CrossRef
The Prospect of the Fourth Industrial Revolution and Home Healthcare in Super-Aged Society Jai-Yon Lee, Jae-Young Lim Annals of Geriatric Medicine and Research.2017; 21(3): 95. CrossRef
Exercise capacity, physical activity, and morbidity Danielle L. Brunjes, Peter J. Kennel, P. Christian Schulze Heart Failure Reviews.2017; 22(2): 133. CrossRef
Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte Andrea Armani, Alessandra Berry, Francesca Cirulli, Massimiliano Caprio The FASEB Journal.2017; 31(10): 4240. CrossRef
Effects of aging and exercise training on the dynamics of vasoconstriction in skeletal muscle resistance vessels Elizabeth M. Gittemeier, Tyler Ericson, Payal Ghosh, Steven W. Copp, Alexander B. Opoku-Acheampong, Bradley J. Behnke European Journal of Applied Physiology.2017; 117(3): 397. CrossRef
The Changing Landscape of Vocal Needs in the Aging Baby Boomer Edie R. Hapner Perspectives of the ASHA Special Interest Groups.2017; 2(15): 24. CrossRef
Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7 Young Jin Jang, Hyo Jeong Son, Yong Min Choi, Jiyun Ahn, Chang Hwa Jung, Tae Youl Ha Oncotarget.2017; 8(45): 78300. CrossRef
FACTORS ASSOCIATED WITH DURATION OF NAPS AMONG COMMUNITY-DWELLING ELDERLY: DATA FROM THE MULTICENTER STUDY FIBRA Ariene Angelini dos Santos-Orlandi, Maria Filomena Ceolim, Sofia Cristina Iost Pavarini, Simone Camargo de Oliveira-Rossignolo, Aline Maino Pergola-Marconato, Anita Liberalesso Neri Texto & Contexto - Enfermagem.2016;[Epub] CrossRef
Assessment criteria for sarcopenia in liver disease (first edition): Report from the working group for creation of sarcopenia assessment criteria in the Japan Society of Hepatology Shuhei Nishiguchi, Keisuke Hino, Kyoji Moriya, Makoto Shiraki, Akira Hiramatsu, Hiroki Nishikawa Kanzo.2016; 57(7): 353. CrossRef
The expression of CG9940 affects the adaptation of cardiac function, mobility, and lifespan to exercise in aging Drosophila Deng-tai Wen, Lan Zheng, Liu Ni, Hui Wang, Yue Feng, Min Zhang Experimental Gerontology.2016; 83: 6. CrossRef
Discrepancies between Skinned Single Muscle Fibres and Whole Thigh Muscle Function Characteristics in Young and Elderly Human Subjects Hyunseok Jee, Jae-Young Lim BioMed Research International.2016; 2016: 1. CrossRef
Physical exercise in aging human skeletal muscle increases mitochondrial calcium uniporter expression levels and affects mitochondria dynamics Sandra Zampieri, Cristina Mammucari, Vanina Romanello, Laura Barberi, Laura Pietrangelo, Aurora Fusella, Simone Mosole, Gaia Gherardi, Christian Höfer, Stefan Löfler, Nejc Sarabon, Jan Cvecka, Matthias Krenn, Ugo Carraro, Helmut Kern, Feliciano Protasi, A Physiological Reports.2016;[Epub] CrossRef
Esercizio fisico, nutrizione e ormoni: il contrasto alla sarcopenia dell’anziano Francesco Romanelli, Massimiliano Sansone, Andrea Lenzi, Luigi Di Luigi L'Endocrinologo.2016; 17(3): 155. CrossRef
Japan Society of Hepatology guidelines for sarcopenia in liver disease (1st edition): Recommendation from the working group for creation of sarcopenia assessment criteria Hiroki Nishikawa, Makoto Shiraki, Akira Hiramatsu, Kyoji Moriya, Keisuke Hino, Shuhei Nishiguchi Hepatology Research.2016; 46(10): 951. CrossRef
Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults Javier Angulo, Mariam El Assar, Leocadio Rodríguez-Mañas Molecular Aspects of Medicine.2016; 50: 1. CrossRef
Bioenergetics of the aging heart and skeletal muscles: Modern concepts and controversies Kersti Tepp, Natalja Timohhina, Marju Puurand, Aleksandr Klepinin, Vladimir Chekulayev, Igor Shevchuk, Tuuli Kaambre Ageing Research Reviews.2016; 28: 1. CrossRef
Composition of Muscle Fiber Types in Rat Rotator Cuff Muscles Yongjun Rui, Feng Pan, Jingyi Mi The Anatomical Record.2016; 299(10): 1397. CrossRef
Body Composition Outcomes of a Qigong Intervention Among Community-Dwelling Aging Adults Mei-Ying Chang, Hsiao-Yu Chen Western Journal of Nursing Research.2016; 38(12): 1574. CrossRef
Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats Melanie M. Das, Pablo Avalos, Patrick Suezaki, Marlesa Godoy, Leslie Garcia, Christine D. Chang, Jean-Philippe Vit, Brandon Shelley, Genevieve Gowing, Clive N. Svendsen Experimental Neurology.2016; 280: 41. CrossRef
Melatonin as a Potential Agent in the Treatment of Sarcopenia Ana Coto-Montes, Jose Boga, Dun Tan, Russel Reiter International Journal of Molecular Sciences.2016; 17(10): 1771. CrossRef
F-BOX proteins in cancer cachexia and muscle wasting: Emerging regulators and therapeutic opportunities Ammar Sukari, Irfana Muqbil, Ramzi M. Mohammad, Philip A. Philip, Asfar S. Azmi Seminars in Cancer Biology.2016; 36: 95. CrossRef
Factors Associated with the Serum Myostatin Level in Patients Undergoing Peritoneal Dialysis: Potential Effects of Skeletal Muscle Mass and Vitamin D Receptor Activator Use Shunsuke Yamada, Kazuhiko Tsuruya, Hisako Yoshida, Masanori Tokumoto, Kenji Ueki, Hiroaki Ooboshi, Takanari Kitazono Calcified Tissue International.2016; 99(1): 13. CrossRef
Morphological and Functional Aspects of Human Skeletal Muscle Francesca Trovato, Rosa Imbesi, Nerys Conway, Paola Castrogiovanni Journal of Functional Morphology and Kinesiology.2016; 1(3): 289. CrossRef
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin Giulia Maria Camerino, Michela De Bellis, Elena Conte, Antonella Liantonio, Kejla Musaraj, Maria Cannone, Adriano Fonzino, Arcangela Giustino, Annamaria De Luca, Rossella Romano, Claudia Camerino, Antonio Laghezza, Fulvio Loiodice, Jean-Francois Desaphy, Toxicology and Applied Pharmacology.2016; 306: 36. CrossRef
Exercise, ageing and the lung Michael A. Roman, Harry B. Rossiter, Richard Casaburi European Respiratory Journal.2016; 48(5): 1471. CrossRef
Intrinsic muscle clock is necessary for musculoskeletal health Elizabeth A. Schroder, Brianna D. Harfmann, Xiping Zhang, Ratchakrit Srikuea, Jonathan H. England, Brian A. Hodge, Yuan Wen, Lance A. Riley, Qi Yu, Alexander Christie, Jeffrey D. Smith, Tanya Seward, Erin M. Wolf Horrell, Jyothi Mula, Charlotte A. Peterso The Journal of Physiology.2015; 593(24): 5387. CrossRef
Fig. 1 Percentage of old people in South Korea (A) in comparison with other developed countries (B) from 1960 to 2050 (projected). OECD, Organization for Economic Co-operation and Development.
Fig. 2 Cellular and molecular changes at the level of muscle fibers that contribute to muscle aging.
