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Journal of the Korean Academy of Rehabilitation Medicine 1996;20(4):39.
Myelopathy following Intrathecal Chemotherapy in a Patient with Malignant Lymphoma
Jin Kyung Na, M.D. , Sei Joo Kim, M.D.
Department of Rehabilitation Medicine, College of Medicine, Korea University
수막강내 화학요법 후 발생한 사지마비의 증례 -증례 보고-
나진경, 김세주
고려대학교 의과대학 재활의학교실

Myelopathy caused by intrathecal chemotherapy has no known pathognomonic features but it is a diagnosis exclusion. A 16-year-old boy with malignant lymphoma(diffuse large cell), who received intrathecal methotrexate developed progressive motor and sensory deficits and quadriplegia below the C7 level. These symptoms were chronologically related to the time since chemotherapy has been begun. He died a month after the beginning of neurologic deficits. Intrathecal therapy of methotrexate in lymphoma must be used with greater caution, especially when neurologic abnormalities are developed during therapy.

Key Words: Methotrexate, Quadriparesis, Intratheral therapy, Malignant lymphoma


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