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Journal of the Korean Academy of Rehabilitation Medicine 1994;18(4):20.
Clinical and Electrodiagnostic Study about Polyneuropathy in Patients with Chronic Obstructive Pulmonary Disease
Jean Yee Noh, M.D., Hyeon Sook Lee, M.D., Kweon Yun, M.D., , Young Ok Park, M.D.
Department of Rehabilitation Medicine, Kwangju Veterans Hospital and Korea Veterans Hospital

and Literature Chonbuk National University

만성 폐쇄성 폐질환 환자들의 다발성 신경병변에 대한 임상 및 전기진단학적 조사
노진이, 이현숙, 윤권, 박영옥
광주 보훈병원 및 한국 보훈병원 재활의학과

The polyneuropathy in patients with chronic obstructive pulmonary disease(COPD) were described several years ago, but are not widely recognized neither well documented. To investigate such polyneuropathy, 41 patients(37 males, 4 females) were included in a prospective study. The incidence, type and distribution of polyneuropathy in the patients with COPD were assessed and also analyzed the causative factor of these results.

The resalts were as follows:

1) In a selected group of 41 patients, electrophysiological signs of polyneuropathy were found in 16 patients depending on diagnostic criteria, and when these divided subgroup, as "definite" group 6 patients, "probable" group 5 patients and "possible" group 5 patients.

2) The patients which were found subclinical polyneuropathy(9 patients, 22%) were more than these that were found clinical polyneuropathy(7 patients, 17%)

3) In the patients with polyneuropathy, lesions were predominant axonal degeneration in motor nerve, and combined with demyelination and axonal degeneration in sensory nerve.

4) In the patients with polyneuropathy, the changes were more involved in leg than arm, more frequently affected sensory fibers, and not only more affected common peroneal nerve in motor nerve conduction study, also sural and ulnar nerve in sensory conduction study.

5) There was a significant correlation between FEV1 and the incidence of polyneuropathy, and then lesions which were thought to be due to hypoxia.

Key Words: Chronic obstructive pulmonary disease, Polyneuropathy


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