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Journal of the Korean Academy of Rehabilitation Medicine 1994;18(4):11.
Clinical Study of Heterotopic Ossification in Traumatic Brain Injury
Ueon Woo Rah, M.D., Gi Young Park, M.D., , Joon Hwan Kim, M.D
Department of Rehabilitation Medicine, Ajou University School of Medicine and Yonsei University College of Medicine
외상성 뇌손상 환자의 이소성 골화증
나은우, 박기영, 김준환
아주대학교 의과대학 및 연세대학교 의과대학 재활의학교실
Abstract

The Purpose of this study was to investigate location, the efficacy of diagnostic tools, and risk factors for heterotopic ossification which was a frequent complication in patients with traumatic brain injury(TBI).

Among the fifty-four patients with TBI, heterotopic ossification was developed in twelve patients(22.2%). The most common location was around the hip joint with the incidence of 59.2%. The significant risk factors related to heterotopic ossification were associated long bone fractures and spasticity. The time of diagnosis of heterotopic ossification among six patients was 3.8 months after TBI. Serum alkaline phosphatase levels were elevated in all eight patients with heterotopic ossification within 12 months after injury. All ten patients who took the bone scan reveled increased activity.

In accordance with close clinical observation, serial laboratory tests are needed in patients with TBI at risk of heterotopic ossification. Serial serum alkaline phosphatase measurement, roentgenography and 3 phase bone scan are required for early diagnosis and evaluation of the maturity of heterotopic ossification

Key Words: Traumatic brain injury, Heterotopic ossification, Risk factor


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