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Journal of the Korean Academy of Rehabilitation Medicine 1987;11(2):12.
Changes of Nerve Conduction after Instillation of Phenol, Procaine and Alcohol Solutions to Peripheral Nerve of Rat
In-Sun Park, M.D. , Kang-Mok Lee, M.D.
Department of Rehabilitation Medicine, College of Medicine Hanyang University
백서의 말초신경에 Phenol, Alcohol 및 Procaine 용액 점적 후의 신경전도변화에 대한 연구
박인선, 이강목
한양대학교 의과대학 재활의학교실

Diluted phenol solution has been used to alleviate spasticity and to control pain since 1955. But the mechanism of nerve block with diluted phenol solution has not been established yet. Sciatic nerve of 46 rats were used to produce nerve block with phenol solution.

Nerve conduction studies before and after nerve block were done, and latency and amplitude of evokded potential were compared, Nerve block with pure alcohol and procaine solution were done and compared with those of diluted phenol solution.

The results were as following;

1) Nerve conduction after phenol block resulted in marked decrement of amplitude of the evoked potentials. Increased amount or increased concentration of phenol solution could produce more complete and permanent nerve block.

2) The degree of phenol nerve block was increased by increased concentration, amount of the solution or applying time of the solution to the nerve.

3) Nerve conduction after nerve block with pure alcohol resulted in decrement of amplitude of evoked potentials, while a little change in the conduction velocities. This results were suggestive of axon was affected more.

4) Nerve conduction after nerve block with procaine solution resulted in prolongation of latency and decrement of amplitude of evoked potentials. This results were suggestive of both compotents were affected.

Key Words: Nerve conduction study, Phenol, Alcohol, Procaine, Nerve block


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