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Journal of the Korean Academy of Rehabilitation Medicine 1997;21(5):841-850.
Findings of Semiquantitative Analysis of 99mTc-HMPAO Brain SPECT in Cerebral Palsy.
Choi, Eun Seok , Yang, Seung Han , Kang, Sae Yoon , Kang, Si Won , Kim, Yong Seog
1Department of Rehabilitation Medicine, The Catholic University College of Medicine, Korea.
2Department of Radiology, The Catholic University College of Medicine, Korea.
뇌성마비에서 99mTc-HMPAO Brain SPECT 검사의 정량적 분석 소견
최은석, 양승한, 강세윤, 강시원*, 김용석
가톨릭대학교 의과대학 재활의학교실 및 방사선과학교실*

It is often difficult, on the basis of clinical examination and conventional investigations, to evaluate the functional impairment of brain in children with cerebral palsy in which early detection remains a challenge. This study was designed to know the usefulness of single photon emission tomography(SPECT) of the brain with technetium-99 m hexamethylpropyleneamineoxime (99mTc-HMPAO) as a semiquantitative method of determination of right-left asymmetries in tracer uptake and a change in antero-posterior regional cerebral blood flow(rCBF) distribution. We investigated 33 children with cerebral palsy aged from 4 months to 48 months(mean 19.3 months). The results were as follows: right to left ratio and regional index of a transverse view were useful to quantify the decrease of tracer uptake in left hemiplegia, but not in right hemiplegia who were all mild in severity, and in tetra- and diplegia in which cerebral lesions were found bilaterally; cortico-cerebellar ratios of a sagittal view were found useful to detect a decrease of rCBF distribution in tetra- and diplegia ,which was not distinct by means of right to left ratio and regional index on transverse view.

The results suggest that semiquantitative analysis of 99mTc-HMPAO Brain SPECT would be a valuable complementary tool for determination of topographical involvement in cerebral palsy.

Key Words: Cerebral palsy, Brain SPECT, rCBF, Quantitative analysis, Topographical involvement


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