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Journal of the Korean Academy of Rehabilitation Medicine 1999;23(2):195-201.
Estimation of Motor Unit Number According to Severity of Peripheral Nerve Injury in Rat.
Shim, Jae Ho , Lee, Ho , Lee, Jong Min , Chung, Hong Guen , Lee, Young Hee
Department of Rehabilitation Medicine, Yonsei University Wonju College of Medicine.
백서에서 말초신경 손상에 따른 운동단위수의 변화
심재호, 이호, 이종민, 정홍균, 이영희
연세대학교 원주의과대학 재활의학교실
Abstract

Objective
To evaluate the changes of motor unit number estimation (MUNE) and the amplitude of compound muscle action potential (CMAP) according to severity of nerve injury in rat.


Method
The sciatic nerve was compressed with two different severity (mild, severe) in 20 rats each. MUNE was performed in gastrocnemius of rat using the Poisson statistics. MUNE and amplitude of CMAP were compared according to severity of injury at two and four weeks after injury.


Results
The MUNE and amplitude of CMAP were significantly diminished at two and four weeks after nerve injury in severely injured rat. Both values were also diminished at two weeks after injury in mildly injured rat. The amplitude of CMAP was slightly increased at four weeks after mild injury despite of further decrement of MUNE.


Conclusion
The MUNE and amplitude of CMAP changed differently according to severity of nerve injury in rat, which might represent different denervation and reinnervation process.

Key Words: Motor unit number estimation, Nerve injury, Regeneration


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