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Journal of the Korean Academy of Rehabilitation Medicine 1999;23(2):430-433.
Two Cases Report of Subacute Combined Degeneration in Association with Folate Deficiency.
Ko, Young Jin , Kim, Hye Won , Lee, Jung Soo , Choi, Soo Jung , Shin, Ji Nam
Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea.
엽산염 결핍증이 동반된 아급성 결합성 척수변성 2예 보고
고영진, 김혜원, 이정수, 최수정, 신지남
가톨릭대학교 의과대학 재활의학교실

Subacute combined degeneration is the clinical syndrome associated with vitamin B12 deficiency and characterized by usually symmetrical weakness and progressively worsening of, and abnormal sensations of the legs, arms, trunk, or other area, mental abnormalities, and vision difficulties. Subacute combined degeneration primarily affects the spinal cord, but it also includes damage to the brain, the nerves of the eye, and the peripheral (body) nerves. In this study, we report two patients with subacute combined degeneration of the cord in association with folate deficiency. Subacute combined degeneration of the spinal cord and optic atrophy occurred only in the patients with vitamin B12 deficiency. However, diet-induced folic acid deficiency and subacute combined degeneration of the spinal cord which improved significantly after treatment with folic acid has been recorded.

Key Words: Subacute combined degeneration, Folate deficiency


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