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Journal of the Korean Academy of Rehabilitation Medicine 1999;23(6):1151-1154.
Experimental Verification of Drug Interaction between Warfarin and Baclofen.
Ko, Hyun Yoon , Park, Jae Heung , Shin, Yong Beom
Department of Rehabilitation Medicine, Pusan National University College of Medicine.
Warfarin과 Baclofen간의 약물 상호 작용의 검증
고현윤, 박재흥, 신용범
부산대학교 의과대학 재활의학교실
Abstract

Objective
A warfarin-baclofen interaction has been postulated, but has not been documented in the literature. The purpose of this study is to investigate the drug interaction between warfarin and baclofen in rats.


Method
Twenty Sprague-Dawley rats (250-300 gm), divided into a control and a study group were used. 0.02 mg/day of warfarin was administered intraperitoneally without baclofen for the first three days. Daily blood samples were drawn after six hours of warfarin adminstration for measurement of prothrombin time (PT) and International Normalized Ratio (INR). On the fourth day, the rats in the study group were given 0.02 mg of warfarin and 0.6 mg of baclofen intraperitoneally. For the control group, 0.02 mg of warfarin was administered on all four days. PT and INR measurements were taken at 3 hours, 6 hours, and 24 hours after the administration of warfarin with or without baclofen.


Results
Mean INR value was significantly increased by concomitant baclofen administration after 6 hours, resulting in 1.72 for the control group with warfarin alone and 2.74 for the study group with warfarin and baclofen (p<0.05).


Conclusion
The concomitant administration of warfarin and baclofen affects the anticoagulant effect of warfarin. Physicians should be aware of the risk for increased anticoagulant effect of warfarin when baclofen is also administered.

Key Words: Warfarin, Baclofen, Drug interaction
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