J Korean Acad Rehabil Med Search


Journal of the Korean Academy of Rehabilitation Medicine 2000;24(2):185-192.
Development of Neuropathic Pain Model with 1% Phenol Injection in Rat Sciatic Nerve.
Lee, Ki Hoon , Lee, Zee Ihn , Kim, Young Eun , Lee, Yang Soo , Kim, Poong Taek , Kim, Myoung Nam
Department of Rehabilitation Medicine, Kyungpook National University College of Medicine.
흰쥐의 좌골신경에 1% 페놀용액을 주입한 실험용 신경병변성 동통모델의 개발
이기훈, 이지인, 김영은, 이양수, 김풍택, 김명남1
경북대학교 의과대학 재활의학교실, 1경북대학교병원 의공학과

The purpose of this study is to develop a new neuropathic pain model in the rat.

Each male adult rat was anesthetized and the sciatic nerve was exposed. Each exposed nerve was injected with 0.03 cc of 1% phenol solution. Normal saline 0.03 cc was injected to the placebo group. Rats were tested for the presence of mechanical allodynia by von Frey hair. Spontaneous pain behavior (paw shaking, paw elevation) was examined for 5 minutes in the cage.

Phenol injected group developed allodynia after the second post-injection day for up to 1 month. Allodynia was also observed in the contralateral legs of phenol injected group. The control group did not develop allodynia. Spontaneous pain behavior was not observed in either group.

Neuropathic pain model was developed by 1% phenol solution injection to the rat sciatic nerve. This study suggests an easier method for making the neuropathic pain model. Key_words: 페놀, 신경병증성 통증 모형, 좌골 신경, Phenol, Neuropathic pain model, Sciatic nerve

Key Words: Phenol, Neuropathic pain model, Sciatic nerve


Browse all articles >

Terms of Use   |   Privacy Polity
Editorial Office
Department of Rehabilitation Medicine, Seoul National University Hospital
101 Daehak-ro, Jongno-gu, Seoul, Korea
Tel: +82-10-8678-2671    Fax: +82-2-6072-5244    E-mail: edit@e-arm.org; edit.karm@gmail.com
Business Registration: 110-82-07460                

Copyright © 2024 by Korean Academy of Rehabilitation Medicine.

Developed in M2PI

Close layer